literature

HIV mutation literature information.

K65R in subtype C HIV-1 isolates from patients failing on a first-line regimen including d4T or AZT: comparison of Sanger and UDP sequencing data.

PMID: 22615779 2012 PloS one

Discussion: The Sanger results of isolates from treated patients were as expected with a predominance of M184V, numerous TAMs of pathway1 (M41L, D67N, K70R, L210W, T215Y/F) and DRMs to NNRTIs (mainly K101E, K103N, V106M, Y181C, G190A).

Assessing subtypes and drug resistance mutations among HIV-1 infected children who failed antiretroviral therapy in Kelantan, Malaysia.

PMID: 22729198 2012 The Brazilian journal of infectious diseases

Abstract: The most prevalent RT mutations were T215F/V/Y (66.7%), D67G/N (55.6%), K219Q/E/R (44.4%), M184V/I (38.9%), K70R/E (27.8%) and M41L (27.8%), associated with nucleoside reverse transcriptase inhibitors (NRTI) resistance; and K103N (55.6%), G190A (33.3%), and K101P/E/H (27.8%) associated with non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance.

Minority variants associated with resistance to HIV-1 nonnucleoside reverse transcriptase inhibitors during primary infection.

PMID: 22818969 2012 Journal of clinical virology

Abstract: Four samples (15%) had a major rilpivirine resistant mutation (E138G, K101E and E138A), 3 of which were detected by UDPS.

Abstract: The 11 RAMs not detected by bulk sequencing were A98G (n=2), L100I (n=3), K101E (n=2), V106I (n=3) and E138G (n=1).

[Genotyping and variability of HIV-1 in 26 cases of paid blood donors].

PMID: 22919750 2012 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: M184V, K101E and G190A were detected in the RT region, respectively.

Identification of drug resistant mutations in HIV-1 CRF07_BC variants selected by nevirapine in vitro.

PMID: 22984494 2012 PloS one

Discussion: Y181C, K103N, G190A, H221Y, K101E, A98G, V108I, V106A, E138A, Y188L are the top ten most common mutations resistant to NVP in patients who received NVP treatment.

HIV-1 drug resistance genotyping from antiretroviral therapy (ART) naive and first-line treatment failures in Djiboutian patients.

PMID: 23044036 2012 Diagnostic pathology

Table: K101E

Virological failure rates and HIV-1 drug resistance patterns in patients on first-line antiretroviral treatment in semirural and rural Gabon.

PMID: 23199801 2012 Journal of the International AIDS Society

Result: Five additional viruses were predicted to be possibly resistant to ETV, including three viruses harbouring the E138A/G/Q/R DRM, one with the three DRMs K101E/H/I/P/R, Y181C, and G190A/S, and one with the three DRMs V90I, K101E/H/I/P/R, and G190A/S.

Result: Major NNRTIs DRMs were also obtained at positions P225H (n=12), K101E (n=11), Y181C (n=10), G190A (n=7), Y188L (n=6), V90I (n=5),

PMID: 23236346 2012 PloS one

Result: The most frequent NNRTI mutations were K103N/S (27.8%), followed by Y181C (22.2%), V108I and G190A (16.7%), Y181V (11.1%), K101E and Y188L (5.6%) (Figure 2).

Table: K101E

Genetic diversity and drug resistance among newly diagnosed and antiretroviral treatment-naive HIV-infected individuals in western Yunnan: a hot area of viral recombination in China.

PMID: 23270497 2012 BMC infectious diseases

Abstract: A total of 1.3% of DR were related to protease inhibitors (PIs), including I85IV, M46I and L90M; 0.3% to nucleoside reverse transcriptase inhibitors (NRTIs), including M184I; and 2.7% to non-nucleoside reverse transcriptase inhibitors (NNRTIs), including K103N/S

Result: Three individuals were found to have one other NNRTI-related mutation (K103NS, K101E and G190A) each (0.33%).

Table: K101E

Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.

PMID: 23305651 2012 Journal of the International AIDS Society

Table: K101E

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