Abstract: Compound 2 was 35-fold more potent than AZT against wild-type virus, and also retained nanomolar antiviral activity against resistant strains, NL4-3 (K
Introduction: K101E tends to decrease viral susceptibility to all nucleoside RT inhibitors, while RTMDR is a multiple RT inhibitor-resistant strain, which is insensitive to AZT, ddI, nevirapine, and other NNRTIs.
Introduction: In our screening, 2 exhibited extremely potent anti-HIV activity against NL4-3 (wild-type), NL4-3 (K101E), and RTMDR, with IC50 values of 0.46, 1.52, and 1.45 nM respectively.
Introduction: In the further evaluation of 2, we discovered that it retained its nanomolar activity against drug-resistant HIV strains including NL4-3 (K101E) and RTMDR (Table 2).
Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital.
PMID: 20576637
2010
The Journal of antimicrobial chemotherapy
Table: K101E
Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants.
Method: NVP-R was defined by mutations present at the following amino acid sites: L100I, K101E/P, K103N/S, V106A/M, V108I, Y181C/I/V, Y188C/L/H, or G190A/S/E based on recommendations from International AIDS Society-USA Drug Resistance Mutations and Stanford University drug-resistance database.
Table: K101E
Emergence of primary NNRTI resistance mutations without antiretroviral selective pressure in a HAART-treated child.
Abstract: Phylogenetic analyses have suggested common ancestry between the mother's virus stra
Method: A second genotyping performed one month after HAART showed K101E, G190A, and T215F.
Method: Analyses for the M50-P50 sequences were performed with and without codon 101 to avoid the effect of convergent evolution of the K101E substitution.
Method: Another test performed 13 months after HAART initiation revealed the persistence of G190A and K101E and the accumulation of various NRTI mutations (Table 1).
Method: Her baseline genotyping test before ARV therapy showed the K101E RT mutation.
Table: K101E
The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy.
Abstract: HIVDR prevalence in Douala was low for PIs and NNRTIs, and moderate for NRTIs as we identified one individual with M184V plus K101E plus G190A mutations and a second with D67D/N.
In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine.
PMID: 19552593
2009
AIDS research and human retroviruses
Introduction: Thirty-six (45.0%) of the 80 infants had at least one NVP resistance mutation detected; the mutations identified were Y181C (n = 28), K103N (n = 9), Y188C (n = 3), G190A (n = 30), V106A (n = 2), V106M (n = 2), and K101E (n = 1); 10 infants had two or more NVP resistance mutations detected.
Table: K101E/P
Virological efficacy and emergence of drug resistance in adults on antiretroviral treatment in rural Tanzania.
HIV mutation literature information.
PMID: 
2010
Letters in drug design & discovery
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