Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina.
PMID: 34085506
2021
Revista espanola de quimioterapia
Abstract: Most frequent PI-RAMs were I85V, M46I, I50V and L90M (n=2, 5% each).
Result: Most frequent PI-RAMS were I85V, M46I, I50V and L90M (n=2, 5% each), all of them with modest impact in the activity of currently available PIs.
Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.
Result: The PI-SDRMs with the lowest treatment/naive prevalence ratios were F53Y (5-fold), V82L (7-fold), M46L (9-fold), and I85V (14-fold).
Discussion: Four PI-SDRMs (M46L, F53Y, V82L, and I85V) had relatively low treated/naive prevalence ratios.
Discussion: Moreover, F53Y, V82L, and I85V have not been linked to reduced susceptibility to the currently used PIs raising the question of whether these mutations will remain useful for the ongoing surveillance of clinically meaningful transmitted PMID: 31922125
2020
EClinicalMedicine
Table: I85V
HIV-genetic diversity and drug resistance transmission clusters in Gondar, Northern Ethiopia, 2003-2013.
Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.
PMID: 28799325
2017
Journal of the International AIDS Society
Table: I85V
HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.
Result: Most PI SDRMs were present only as low-abundance variants under the 5% threshold, including L23I, D30N, I47V, I50V, F53L, I54T, G73S, V82A, N83D, I84V, I85V, N88DS, and L90M (Fig 2).
Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis.
Result: M46I/L, I85V, and L90M were the four most common PI SDRMs in SSA and SSEA, and among the six most common SDRMs in all regions.
Result: In all regions, the proportion of PI-treated individuals with M46L or I85V divided by the number of ARV-naive individuals with these SDRMs was much lower than the same proportion for all other commonly occurring SDRMs.
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
Result: In the experienced subgroup, at least seven major (M46I, V82A, I54V, L90M, I84V, M46L, and L76V) and 15 accessory mutations (I62V, A71V, L10I, L10V, K20R, L33F, Q58E, K20T, L10F, T74S, F53L, K43T, G73S, I85V, and A71I) developed and were ass
HIV mutation literature information.
PMID: 
2022
PloS one
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