literature

HIV mutation literature information.

Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.

PMID: 31920003 2020 The FEBS journal

Result: L10I and L63P did not show structural changes in PRS5B but have been shown to help maintain thermal stability when combined with I84V.

Result: PR20 also contains the active site mutation I84V, which works synergistically with 3 other mutations to substantially increase the size of the inhibitor binding cavity as shown by 2 A bigger distance between the closest atoms of Val47 and Val84 and thus decrease the affinity for PIs.

Result: PR20 shows an expanded inhibitor binding cavity due to a cluster of mutations (D30N, V32I,

[Prevalence of transmitted drug resistance in HIV-infected treatment-naive patients in Chile].

PMID: 33844760 2020 Revista medica de Chile

Abstract: The mutations in reverse transcriptase were M41L, L210W, D67N, K70E, M184V, K103N (6.36%, 95% CI 3.5-10.4), G190A, E138A, K101E, and I84V in protease.

Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017).

PMID: 31922125 2020 EClinicalMedicine

Table: I84V

Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2.

PMID: 31965175 2020 The Journal of infectious diseases

Abstract: In PR, 12 nonpolymorphic TSMs occurred in >=11 persons: V33I, K45R, V47A, I50V, I54M, T56V, V62A, A73G, I82F, I84V, F85L, L90M.

HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.

PMID: 32041622 2020 AIDS research and therapy

Table: I84V

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors.

PMID: 32430025 2020 Retrovirology

Abstract: In this study, mutations N88S and L76V, along with three other resistance-associated mutations, M46I, I50L, and I84V, are analysed by means of molecular dynamics simulations to investigate their role in complexes of the protease with different inhibitors and in different background sequence contexts.

Abstract: RESULTS: Using these simulations for alchemical calculations to estimate the effects of mutations M46I, I50L, I84V, N88S, and L76V on binding free energies shows they are in general in line with the mutations' effect on [Formula: see text] values.

Genotyping and antiretroviral drug resistance of human immunodeficiency Virus-1 in Jazan, Saudi Arabia.

PMID: 33285702 2020 Medicine

Abstract: Mutations associated with antiretroviral drugs include (V82A+I84IV), (L10F+Q58E), (L10F+V82Y), L10FV,

Discussion: The most frequent mutations detected in this study were V82A + I84IV which are associated with PI conferring resistance to Atazanavir, Lopinavir, Lamivudine, Emtricitabine, Darunavir, and Abacavir.

Discussion: The mutations associated with resistance to PI were V82A + I84IV 1.8%, and L10F + Q58E 1.8%.

Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.

PMID: 33014372 2020 SAGE open medicine

Table: I84V

Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China.

PMID: 32183889 2020 Virology journal

Table: I84V

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa.

PMID: 32265875 2020 Frontiers in microbiology

Result: The most common major PI RAMs observed were M46I and V82A (n = 12; 12%); I54V (n = 10; 10%); I84V and L76V (n = 7; 7%); I47A/V (n = 3; 3%); I50L/V (n = 2; 2%); and V32I (n = 2; 2%) (Table 1).

Table: I84V

Discussion: The group receiving AZT plus 3TC or ABC plus 3TC showed the highest rate of PIs such as I54V, I84V, L76V, I47A/V, I50L/V, and V32I.

Browser Board

Co-occurred Entities

Filtrator