literature

HIV mutation literature information.

Use of dolutegravir in two INI-experienced patients with multiclass resistance resulted in excellent virological and immunological responses.

PMID: 25397500 2014 Journal of the International AIDS Society

Table: I54V

Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.

PMID: 25397495 2014 Journal of the International AIDS Society

Abstract: RESULTS: The patients had TDRMs to NRTIs (K65R, M184V), NNRTIs (K101E, K103N/S, G190A/E/S, Y181I/C, Y188H/L) and PIs (M46L, I54V, L76V, V82L/T, N83D, I84V, L90M).

A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses.

PMID: 25259833 2014 AIDS (London, England)

Result: Of the 243 patients who received one or more protease inhibitors, 32 (13%) had a study-defined protease inhibitor-resistance mutation most commonly L10F, K20T, V32I, L33F, M46I/L, I47V/A, I50L, F53L, I54V/L, Q58E, L76V, V82A/C, I84V, L89V, and L90M.

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease.

PMID: 25136270 2014 Journal of chemical theory and computation

Abstract: Flap+ is a multidrug-resistant variant of HIV-1 protease with a combination of primary and secondary resistance mutations (L10I, G48V, I54V, V82A) and a strikingly altered thermodynamic profile for darunavir (DRV) binding relative to the wild-type protease.

Introduction: This variant Flap+ (L10I/G48V/I54V/V82A) was derived as a combination of mutations that simultaneously occur in patient sequences.

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF.

PMID: 25108107 2014 Journal of molecular graphics & modelling

Introduction: The multidrug-resistant (MDR)-769 HIV-1 protease consists of amino acid substitutions: L10I, M36V, M46L, I54V, I62V, L63P, A71V, V82A, I84V and L90M.

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.

PMID: 25575025 2014 Retrovirology

Method: Baseline patient-derived viral protease genes harboring M46I, M46L, L90M or I54V + V82A + L90M or the N-terminus of RT containing M41L

Result: In addition, two more complex transmitted viruses were studied: a protease-variant containing I54V + V82A + L90M and an RT-variant carrying M41L + T69S + L210E + T215S.

Table: I54V

Cooperative effects of drug-resistance mutations in the flap region of HIV-1 protease.

PMID: 23252515 2013 ACS chemical biology

Introduction: Additionally, the effect of individual mutations I54V versus I54A on inhibitor binding is compared.

Introduction: Analysis of patient sequences in the Stanford HIV drug resistance database revealed that I54A also shares many of the mutations frequently observed together with I54V (detailed analysis in Supplementary Information).

Introduction: As mentioned previously, the binding of Flap+(I54V) to both APV and DRV was enthalpically unfavorable, and these reactions were entirely driven by the entropy of binding (Table 1).

Potential elucidation of a novel CTL epitope in HIV-1 protease by the protease inhibitor resistance mutation L90M.

PMID: 24015196 2013 PloS one

Result: Five sequence sets were constructed, each devoid of M46I, I54V, V71A, V82A and I84V respectively, which were referred to as clean slate sets.

Result: Measurement of the impact of M46I, I54V, V71A, V82A, I84V frequencies on the frequency of L90M, was accomplished by the construction of a linear model.

Result: The frequencies commonly occurring PR mutations, M46I, I54V, A71V, V82A and I84V were a

Persistence of HIV-1 transmitted drug resistance mutations.

PMID: 23904291 2013 The Journal of infectious diseases

Table: I54V

Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina.

PMID: 24093951 2013 Journal of the International AIDS Society

Table: I54V