High resistance to reverse transcriptase inhibitors among persons infected with human immunodeficiency virus type 1 subtype circulating recombinant form 02_AG in Ghana and on antiretroviral therapy.
Abstract: Additionally, and at a lower level, protease inhibitor (PI)-resistance mutations, M46I, I54 V, V82A, L90 M, and I471 V, were also present in the sequences from antiretroviral therapy (ART)-experienced individuals.
HIV-1 subtypes and drug resistance mutations among female sex workers varied in different cities and regions of the Democratic Republic of Congo.
Result: The two non-polymorphic accessory mutations associated with PI mutations were L33F and I54V, and were observed in three PI resistant patients.
Table: I54V
HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.
Result: M46I and I54V mutations co-occur frequently in drug resistance.
Result: PRS17 contains a cluster of three flap mutations, M46L, G48V, and I54V, which primarily affect the conformation of the flaps.
Result: Adding M46I and I54V mutations to a RTV-resistant mutant was shown to improve catalytic efficiency while sustaining resistance.
Result: In PRS5B structures, the shorter sidechain of I54V decreases hydrophobic interactions with the Ile50 side chain on the opposite subunit.
Result: PRS5B contains 22 mutations, including only a single mutation (I84V) in the inhibitor binding site and two mutations (
Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.
PMID: 33654530
2020
The Pan African medical journal
Abstract: Predominant NNRTIs mutations were K103N (15), Y181C (9), G190A (7), and H221Y (6) NRTIs, M184V (17), Y115F (5) and PIs, I54V (4).
Result: Predominant NNRTIs mutations were K103N, Y181C, G190A, H221Y, and Discussion: PI major mutations were identified with I54V, F53L, V82A being prevalent.
Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population.
Result: Of the 203 PI-associated SDRMs, the most common were L90M (33.5%), M46I/L (19.7%), I54V (10.8%), V82A/L/T (10.4%), and D30N plus N88D (9.8%).
Evolution of Protease Inhibitor Resistance in Human Immunodeficiency Virus Type 1 Infected Patients Failing Protease Inhibitor Monotherapy as Second-line Therapy in Low-income Countries: An Observational Analysis Within the EARNEST Randomized Trial.
Result: A Kaplan-Meier analysis could be performed for 18 TDRMs (K20T, L23I, K43T, M46I/L/V, I54V, M41L, L74I, M184V, L210W, K219R, T215A/C/D/N/S and T215Y).
Discussion: In concordance with the three other studies on the persistence of TDRMs, for most PI mutations (I54V, K43T, L23I, M46I/L/V) a long mean survival time between 2.2 and 4.2 years was found in our st
Characterisation of protease resistance mutations in a South African paediatric cohort with virological failure, 2011 - 2017.
HIV mutation literature information.
PMID: 
2020
Medicine
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