Minority resistant variants are also present in HIV-2-infected antiretroviral-naive patients.
PMID: 29415189
2018
The Journal of antimicrobial chemotherapy
Abstract: The most prevalent MRV was the PI RAM I50V detected in three samples.
Characterization of minority HIV-1 drug resistant variants in the United Kingdom following the verification of a deep sequencing-based HIV-1 genotyping and tropism assay.
Abstract: George's, mainly M46I/L and I50 V (associated with PIs), D67 N, K65R, L74I, M184 V/I, and K219Q (NRTIs), and L100I (NNRTIs).
Result: Most of the minority mutations in viruses from both groups of naive patients were observed in the RT, e.g., M41L, E44D, A62V, K65R, D67N, D67G, V75I,
Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations.
PMID: 29847122
2018
Journal of chemical theory and computation
Abstract: In this study, we analyze ten different protease-inhibitor complexes carrying major resistance-associated mutations (RAMs) G48V, I50V, and L90M using molecular dynamics simulations.
Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Result: The 3 most prevalent HIV-1 resistance-associated mutations for PRO were L63P (73.9%), V77I (45.2%) and I13V (34.2%), whereas I50L, I50V and K20I were the least abundant mutations recorded during the 10-year period (Figs 2 and 4).
HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.
Result: Most PI SDRMs were present only as low-abundance variants under the 5% threshold, including L23I, D30N, I47V, I50V, F53L, I54T, G73S, V82A, N83D, I84V, I85V, N88DS, and L90M (Fig 2).
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
PMID: 26414663
2016
AIDS research and human retroviruses
Abstract: Nonnucleoside reverse transcriptase inhibitor-associated TDRMs were detected in 3.3% (44/1,306) of patients (L100I, K101E/P, K103N/S, V179F, Y188H/L/M, Y181I/C, and G190A/E/S) and TDRMs to protease inhibitors were detected in 2.3% (30/1,306) of patients (M46L, I50V, I54V, Q58E, L76V, V82A/C/L/T, N83D, I84V, and L90M
Computational Studies of a Mechanism for Binding and Drug Resistance in the Wild Type and Four Mutations of HIV-1 Protease with a GRL-0519 Inhibitor.
PMID: 27240358
2016
International journal of molecular sciences
Result: However, the averaged distances over the last 40 ns of MD are 5.92 and 7.63 A for the WT and I50V complexes, respectively (Figure 6).
Result: So the distances between the two CA atoms of Val50 and Val50' become larger in the I50V complex relative to in the WT complex.
Result: The averaged RMSDs values of D30N, I50V, I54M, and V82A are 1.42, 1.21, 1.36, and 1.07 A, respectively.
Result: The averaged value of psi angles of residue 50 in chain B of WT and I50V systems are 133.36 and -42.28 , respectively.
Result: The calculated binding free energies are -23.79, -20.72, -19.65, -21.18, and -21.86 kcal/mol for WT, D30N, I50
A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients.
Abstract: In fact, the structural variant of the IL4RA I50V, previously shown to result in enhanced signal transduction, was significantly associated with greater cavity size, and a variant of IL13RA2 was associated with disease in females.
Method: Genetic variants of the IL4, IL13, IL4R, IL13RA1, and IL13RA2 were selected due to evidence of association with and functional significance in the TH2-related condition asthma (IL4-589, rs2243250; IL13-1112, rs1800925; IL4R I50V, rs1805010; IL13RA1, rs2495636) and tissue pathology (IL13RA2, rs5946040).
Result: In striking contrast, the IL4R genotype A/A (I50V), when compared to the genotypes A/G and G/G, occurred more frequently among patients with high radiological severity scores for cavities compared to those with low ones (odds ratio (OR) 1.32, 95% confidence interval (CI) 1.0-1.7, p value 0.05).
Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.
Result: Each rFS5929R1 virus without I47V (rFS5929R1I47) and rFS5929R1 without I50V (rFS5929R1I50) exhibited a >175-fold and 96.9-fold increase in DRV resistance, respectively, whereas the rFS5929R1 without the two mutations (rFS5929R1I47/I50) exhibited a 20.4-fold increase.
Result: Interestingly, the regions included the two major DRV resistance mutations (I47V and I50V) and one minor mutation (V32I), which were induced by the in vitro selection (Figure 3C).
Result: The major virus (referred to as FS5929R1) had two major DRV resistance mutations (I47V and I50V), four minor mutations (V11I, V32I, L33F, and L89V
HIV mutation literature information.
PMID: 
2018
The Journal of antimicrobial chemotherapy
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