literature

HIV mutation literature information.

HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy.

PMID: 32556165 2020 The Journal of antimicrobial chemotherapy

Table: I34L

Molecular epidemiology of HIV in two highly endemic areas of northeastern South Africa.

PMID: 22189822 2012 Archives of virology

Result: The amino acid alignments of the gag p17 and p24 showed no difference between their consensus sequences and the global subtype C consensus sequence, but they differed from the South African vaccine strain at seven positions (E11G, K15A, H27Q, I34L, M61I, K75R, and C111S) for the gag p17 and four positions (I91V, N125S, V129I and R151K) in the gag p24 region.

Identification and characterization of HLA-A*0301 epitopes in HIV-1 gag proteins using a novel approach.

PMID: 19903485 2010 Journal of immunological methods

Introduction: Our previous study of HIV-1 gag in a large HIV-1-infected cohort (N=431) identified three positively selected (PS) amino acids, V7I and I34L in the p17 region of gag (unpublished) and K403R in the p7 region of gag.

Introduction: The K403R mutation was found to be significantly associated with A*0301 after multiple test corrections in and following reanalysis of the raw data, the V7I and I34L mutations were also found to be associated with A*0301.

Method: The V7I and I34L were both found to be significant in this study even though they missed t

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