literature

HIV mutation literature information.

Tipranavir: a ritonavir-boosted protease inhibitor.

PMID: 16060700 2005 Drugs

Abstract: Analysis of clinical isolates from treatment-experienced patients identified the following tipranavir resistance-associated HIV protease mutations: L10V, I13V, K20M/R/V, L33F, E35G, M36I, K43T, M46L, I47V, I54A/M/V, Q58E, H69K, T74P, V82L/T, N83D, I84V.

High incidence of non-B and recombinant HIV-1 strains in newly diagnosed patients in Galicia, Spain: study of genotypic resistance.

PMID: 14518705 2003 Antiviral therapy

Abstract: Several polymorphisms in RT: D123S, Q174K, D177E, T200A, V245Q, and PR: I13V, K20I, M36I, R41K, H69K, L89M were detected more frequently in non-B and recombinants than in B strains (P<0.01 to P<0.001).

Genetic variability of HIV-1 protease from Nigeria and correlation with protease inhibitors drug resistance.

PMID: 11324755 2001 Virus genes

Abstract: The protease amino acid consensus sequence of the Nigerian subtype A are in complete agreement with the consensus A differing from the USA subtype B consensus in 10 positions (L10V, I13V, K14R, I15V, K20I, M36I, R41K, P63L, H69K and L89M).

Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes.

PMID: 11353856 2001 Proc Natl Acad Sci U S A

Abstract: The A protease used in these studies differs in seven positions (I13V/E35D/M36I/R41K/R57K/H69K/L89M) in relation to the consensus B subtype protease.

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