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 HIV mutation literature information.


  Correlation between resistance profile and immunosuppression in heavily treated HIV-1 infected Romanian patients.
 PMID: 22180722       2011       Romanian biotechnological letters
Result: Additional PI-selected accessory mutations were found only in the severe immunosuppressed group and include the highly polymorphic mutations I13V (23.8%), D60E (14.3%) and K55R, an uncommon non-polymorphic mutation.


  Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score.
 PMID: 22110581       2011       PloS one
Table: I13V


  Interpretation of genotypic HIV-1 resistance to darunavir and virological response: validation of available systems and of a new score.
 PMID: 21685536       2011       Antiviral therapy
Abstract: The DRV-2009 score V11I+L33F+R41K+I47V+2*I50V+2*I54M+K55R+D60E+L74P+L76V+N88D+2*L89V-L10I/V-I13V-G16E-G48V-F53I/L-I62V-I66F-V77I (<0 indicating susceptibility, 0-1 intermediate resistance and >=2 resistance) correlated with VR in the derivation set (n=132, R=0.395; P<0.001).


  The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?
 PMID: 21314993       2011       AIDS research and therapy
Table: I13V


  Update of the drug resistance mutations in HIV-1: December 2010.
 PMID: 21245516       2010       Topics in HIV medicine
Abstract: The mutations I13V, K20M/R, E35G, and L90M were removed from the tipranavir/ritonavir bar, reflecting new understanding.


  Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naive subjects in the CASTLE study.
 PMID: 20532178       2010       PloS one
Table: I13V


  Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure.
 PMID: 20009919       2010       AIDS (London, England)
Abstract: Compared to the subtype B consensus, six additional polymorphisms (I13 V
Result: There were six differences between the consensus sequence inferred from our dataset and the subtype B consensus sequence (I13V, E35D, M36I, R41K, H69K and L89M).
Discussion: I13 V and E35D often appear during nelfinavir treatment.


  Virological efficacy and emergence of drug resistance in adults on antiretroviral treatment in rural Tanzania.
 PMID: 19583845       2009       BMC infectious diseases
Table: I13V


  Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda.
 PMID: 19276794       2009       AIDS (London, England)
Table: I13V


  Tipranavir resistance associated mutations in protease inhibitor-naive patients with HIV-1 subtype A/E infection.
 PMID: 18701346       2008       Journal of clinical virology
Abstract: Patients with subtype A/E had higher prevalence of I13V (54% vs. 21%, P=0.011), M36I (96% vs. 53%, P<0.001), H69K (68% vs. 26%, P=0.001), and >2 TPV-RAMs (62% vs. 21%, P=0.002).
Abstract: The most common TPV-RAMs were M36I (88%), H69K (61%), and I13V (48%).



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