Discussion: I13V/A, K20I, M36I/L, R41K, H69K/R and L89M are the consensus mutations identified for subtypes G, UG and CRF02_AG while E35Q, R57K/G, C67E/S and V82I are the consensus mutations for G and UG in this study.
Discussion: A study on PI-naive Nigerian HIV-patients have earlier identified I13V, M36I and H69K as wild-type consensus mutations for HIV-1 subtypes G', G, CRF02_AG, CRF06_cpx, and A.
Discussion: Other mutations/polymorphisms that occurred at very high frequencies
Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
Result: PRS17 and PR20 also have additional compensating mutations that act synergistically with M36I (K20R in PRS17 and I33F, I13V and I15V in PR20) to further stabilize the hinge.
Genetic Diversity and Drug Resistance of HIV-1 CRF55_01B in Guangdong, China.
Abstract: CRF55_01B contains polymorphisms I13I/V, G16E and E35D that differ from those in CRF01_AE.
Emergence of Resistance to Integrase Strand Transfer Inhibitors during Dolutegravir Containing Triple-Therapy in a Treatment-Experienced Patient with Pre-Existing M184V/I Mutation.
Result: In addition, the accessory protease mutations K20R, L10I, I13V, and G16E were detected.
HIV Viral Rebound Due to a Possible Drug-Drug Interaction between Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide and Calcium-Containing Products: Report of 2 Cases.
PMID: 30798679
2019
Journal of the International Association of Providers of AIDS Care
Conclusion: The genotype performed at this time showed the following protease inhibitor gene mutations: I13I/V, E35D, D60E, L63P, I64V, and V77I and RT mutation V106I/V/M conferring resistance to efavirenz and nevirapine.
A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002-2011.
Result: The 3 most prevalent HIV-1 resistance-associated mutations for PRO were L63P (73.9%), V77I (45.2%) and I13V (34.2%), whereas I50L, I50V and K20I were the least abundant mutations recorded during the 10-year period (Figs 2 and 4).
Discussion: The third most abundant PRO mutation that we observed-I13V -is associated with fast virologic failure and decreased drug affinity.
Conformational variation of an extreme drug resistant mutant of HIV protease.
PMID: 26397743
2015
Journal of molecular graphics & modelling
Method: Plasmid DNA encoding PR (subtype B of group M) with 20 mutations Q7K; L10F; I13V; I15V; D30N; V32I; L33F; E35D; M36I; S37N; I47V; I54L; Q58E; I62V; L63P; A71V; I84V; N88D; L89T and L90M (termed PR20) cloned between the Nde1 and BamH1 sites
Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.
HIV mutation literature information.
PMID: 
2021
Journal of molecular graphics & modelling
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