literature

HIV mutation literature information.

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa.

PMID: 32265875 2020 Frontiers in microbiology

Result: H221Y and M230L occurred in one (1%) patient each; both these patients were receiving AZT plus 3TC.

Table: H221Y

Natural presence of the V179D and K103R/V179D mutations associated with resistance to nonnucleoside reverse transcriptase inhibitors in HIV-1 CRF65_cpx strains.

PMID: 32345262 2020 BMC infectious diseases

Result: V179D, Y181C, and H221Y were detected in the one treatment-experienced patient.

Table: H221Y

The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China.

PMID: 32381145 2020 Epidemiology and infection

Result: Among the key DRMs for NNRTIs, Y188C/F/L (0.9%, 3/322), K103N (0.6%, 2/322) and G190A (0.3%, 1/322) conferred high-level resistance, K101E (0.9%, 3/322) and P225H (0.9%, 3/322) conferred intermediate resistance and H221Y (0.9%, 3/322) conferred low-level resistance.

Table: H221Y

Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi.

PMID: 32434561 2020 AIDS research and therapy

Table: H221Y

Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.

PMID: 33654530 2020 The Pan African medical journal

Abstract: Predominant NNRTIs mutations were K103N (15), Y181C (9), G190A (7), and H221Y (6) NRTIs, M184V (17), Y115F (5) and PIs, I54V (4).

Result: Predominant NNRTIs mutations were K103N, Y181C, G190A, H221Y, and K101E; NRTIs were M184V, Y115F, Table: H221Y

Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.

PMID: 32576136 2020 BMC infectious diseases

Figure: Note: PIs mutations: M46I, I54V, V82A, K20T, L10F/LFI and Q58E/QE; NRTIs mutations: D67N/DN, K70R/KR/T, M184V/MV/I, T215F/FS/TNSY, K219Q, K65R, L74I/LI/LV, Y115F, L210W, M41L and V75I; NNRTIs mutation:

PMID: 33014372 2020 SAGE open medicine

Table: H221Y

Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia.

PMID: 32993693 2020 Retrovirology

Result: Both CPR tool and IAS-USA algorithms were concordant in identifying five NNRTIs resistance-associated mutations: K103N in one patient (1.96%), Y188L, and H221Y in another patient (1.96%), K101E in one patient (1.96%), and V106A in another patient (1.96%).

Table: H221Y

Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern Tanzania.

PMID: 32986709 2020 PloS one

Table: H221Y

Review of Doravirine Resistance Patterns Identified in Participants During Clinical Development.

PMID: 32925358 2020 Journal of acquired immune deficiency syndromes (1999)

Method: Among these, 5 isolates showed RT V106 (V106I, V106V/I, V106A, and V106M/T) substitutions in combination with one or more of A98A/G, H221H/Y, P225P/H, F227 (as F227C or F227C/R), or Y318Y/F RT substitutions, and 1 had genotypic resistance conferred through a Y188L substitution alone.

Method: Among those with PDVF who were tested, 2 DOR-treated participants develo

Table: H221H/Y

Browser Board

Co-occurred Entities

Filtrator