literature

HIV mutation literature information.

Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report.

PMID: 30503324 2018 The lancet. HIV

Result: SGS detected minor resistance mutations in the PR gene that were not reported in the standard genotype (D30N (3.6%), G73S (1.8%) and G48E (5.5%).

Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.

PMID: 29026792 2017 Iranian journal of public health

Abstract: The analysis of reverse transcriptase showed M184V (68.9%), T215YISF (44.8%), K103N (27.6%) and the analysis results of protease revealed G73SC (13.8%) and I47VA (6.9%).

Result: For PIs, G73SC and I47VA were observed as the most common minor and majo

Discussion: G73SC mutation is associated with reduced susceptibility to nelfinavir and saquinavir.

HIV-1 genetic diversity and transmitted drug resistance frequency among Iranian treatment-naive, sexually infected individuals.

PMID: 28181034 2017 Archives of virology

Abstract: Two minor HIV protease-inhibitor-related mutations (L10I and G73S) were detected in two patients, but these mutations are not included in the WHO SDRMs list.

Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.

PMID: 27992544 2016 PloS one

Result: This inactive protease with active site D25N mutation has 22 other mutations (L10I, V11I, L23I, V32I, L33F, S37N, M46I, I47V, I50V, F53L, I54V, Q58E, D60E, L63P, H69R, A71V, G73S, V77I, V82F, L89V, L90M, <

Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.

PMID: 26870021 2016 Frontiers in microbiology

Table: G73S

HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.

PMID: 27736898 2016 PloS one

Result: Most PI SDRMs were present only as low-abundance variants under the 5% threshold, including L23I, D30N, I47V, I50V, F53L, I54T, G73S, V82A, N83D, I84V, I85V, N8

Discussion: Only four of the patients with M41L (all with long-standing infection) also presented other low-abundance DR variants (<5%): K103N, Y181C, K65R, and PR G73S.

The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.

PMID: 26543866 2015 BioMed research international

Result: In the experienced subgroup, at least seven major (M46I, V82A, I54V, L90M, I84V, M46L, and L76V) and 15 accessory mutations (I62V, A71V, L10I, L10V, K20R, L33F, Q58E, K20T, L10F, T74S, F53L, K43T, G73S, I85V, and A71I) developed and were ass

Outcome of patients on second line antiretroviral therapy under programmatic condition in India.

PMID: 26572102 2015 BMC infectious diseases

Table: G73S

Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.

PMID: 26107265 2015 PloS one

Table: G73S

Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.

PMID: 26010948 2015 PloS one

Table: G73S

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