literature

HIV mutation literature information.

Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals.

PMID: 23443042 2013 Journal of the International AIDS Society

Table: G190S

Transmission patterns of HIV-subtypes A/AE versus B: inferring risk-behavior trends and treatment-efficacy limitations from viral genotypic data obtained prior to and during antiretroviral therapy.

PMID: 23469241 2013 PloS one

Result: Twenty-three, including 21 for whom these drugs where part of their first-line the

Table: G190A/S

Table: G190S

Reverse transcriptase backbone can alter the polymerization and RNase activities of non-nucleoside reverse transcriptase mutants K101E+G190S.

PMID: 23535575 2013 The Journal of general virology

Abstract: However, L100I and K101E reduced the amount of RT in the virions and subsequent addition of L74V restored RT levels back to those of G190S or K103N alone.

Abstract: We found that L100I, K101E and L74V did not change the polymerization or RNase H activities of K103N or G190S RTs.

Abstract: We measured the amount of RT in virions and the polymerization and RNase H activities of mutant RTs compared to wild-type, K103N<

Evaluation of WHO immunologic criteria for treatment failure: implications for detection of virologic failure, evolution of drug resistance and choice of second-line therapy in India.

PMID: 23735817 2013 Journal of the International AIDS Society

Method: Non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations that we assessed included K103N, Y181C, Y181I, G190A, G190S, V108I, Y188L, V106M, K103NS, K101E and G190E.

Reverse transcriptase backbone can alter the polymerization and RNase activities of non-nucleoside reverse transcriptase mutants K101E+G190S.

PMID: 23804564 2013 The Journal of general virology

Abstract: D10 virions also had increased amounts of RT compared to K101E+G190S in the NL4-3 backbone.

Abstract: In contrast, RTs with the D10 backbone had increased RNase H activity compared to WT and K101E+G190S in the NL4-3 backbone.

Abstract: Viruses with the mutant combination K101E+G190S replicated better in the presence of NNRTIs than in the absence of drug.

Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity.

PMID: 23806074 2013 Biochemistry

Method: HIV-1 RT wild type (WT) protein (p66/p51 dimer, NL4-3), (specific activity = 5400 U/mg), patient RT isolate, K101E+G190S+M41L +T215Y, (D10) (specific activity = 7500 U/mg) were expressed and purified in our laboratory as previously described .

Result: The mutant D10 (K101E+G190S+M41L+T215Y) was isolated from a patient who had failed efavirenz treatment .

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

PMID: 23840622 2013 PloS one

Method: Different RT mutations at the same residue were pooled, including the NRTI-resistance mutations D67NG, K70EGQ, L74VI, M184VI, T215YF, K219QE and the NNRTI-resistance mutations K101EH, K103NS, Y188LCH, and G190ASEQ.

Method: The following non-polymorphic ARV-selected mutations were classified as drug resistance mutations (DRM): (i) the NRTI resistance mutations M41L,

PMID: 23977189 2013 PloS one

Abstract: No transmitted HIV-1 drug-resistance mutation was found in 59 ART-naive adults, but K103N and G190S mutations were observed in one ART-naive child.

Result: Importantly, among the 10 ART-naive children, a 1.5-year-old case had K103N and G190S NNRTI-resistance mutations (Table 5), suggesting the importance of HIV-1 drug-resistance testing in infants.

Result: In this case, both 3TC-resistance (M184V) and EFV-resistance (V108I and G190S) mutations were detected (Table 5).

Prevalence and mutation patterns of HIV drug resistance from 2010 to 2011 among ART-failure individuals in the Yunnan Province, China.

PMID: 24009694 2013 PloS one

Table: G190S

Increased risk of Q151M and K65R mutations in patients failing stavudine-containing first-line antiretroviral therapy in Cambodia.

PMID: 24015311 2013 PloS one

Result: The most frequently detected mutations were: M184I/V (92.3%), Y181C/I/V (47.1%), T215I/C/F/N/S (38.8%), D67E/G/N (37.3%), K103N/R/S (33.9%), and G190A/Q/S (32.5%).

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