literature

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Discussion: Results from the HIV-1 drug resistance mutation research by the International AIDS Society-USA (updated in March 2013) have revealed that PI resistance mutation sites are L10I, K20M, V32I, M36I, M46I/L, I47V/A, I50V, Q58E, A71V, G73S, V82A/F/T, I84V, L89V,L90M; NRTIs resistance mutations are M41L, A62V,

PMID: 24633208 2014 The Journal of antimicrobial chemotherapy

Result: Individual mutations observed were G190AS (n = 8; 47%), Y181CV (n = 6; 35%), K101I (n = 3; 18%), A98G (n = 2; 12%), K103N (n = 2; 12%) and V108I (n = 1; 6%).

Transmitted drug resistance to rilpivirine among antiretroviral-naive patients living with HIV from northern Poland.

PMID: 24746180 2014 Journal of the International AIDS Society

Introduction: Moreover, in numerous in vivo and in vitro studies, other candidate drug resistance mutations have been identified, including V90I, L100I, K101H/T, V106L, E138S,V179F/D/G/I/T, V189, G190A/E/S, F227L and M230V.

Method: RPV resistance-associated mutations were divided into key resistance mutations (K101E/P, E138A/G/K/Q/R, V179L,Y181C/I/V, Y188L, H221

Prevalence and patterns of drug-resistance mutations among HIV-1 patients infected with CRF07_BC strains in Sichuan province, China.

PMID: 25160759 2014 Virologica Sinica

Abstract: The most common mutation in the ART-failure group was M184V (35.88%), K103N (45.01%), Y181C (17.33%), and G190S/A (15.88%).

A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses.

PMID: 25259833 2014 AIDS (London, England)

Abstract: G190S was the most common nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation, occurring in 55 (33%) subtype A(FSU) viruses from 167 NNRTI-experienced patients compared with none of 37 CRF02_AG viruses from NNRTI-experienced patients (P < 0.001).

Abstract: CONCLUSION: The predisposition of subtype A(FSU) to G190S is concerning because G A is the most common HIV-1 mutation and because G190S causes higher levels of nevirapine and efavirenz resistance than K103N.

Abstract: Therefore, G190S results from a single G A transition: G (GGC) S (AGC) almost exclusively in subtype A(FSU) viruses.

A significant reduction in the frequency of HIV-1 drug resistance in Quebec from 2001 to 2011 is associated with a decrease in the monitored viral load.

PMID: 25295725 2014 PloS one

Discussion: In TN individuals, M41L (2.1%), M184I/V (2.6%), K103N/S (3.65%) and G190A/S (3.67%) were the most common mutations detected.

Discussion: Our results show that since 2004, the frequency of K103N/S increased from 1.5% before 2003 to 4.1% in 2011 while G190A/S frequency decreased from 5.6% to 3.1%.

Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.

PMID: 25397495 2014 Journal of the International AIDS Society

Abstract: RESULTS: The patients had TDRMs to NRTIs (K65R, M184V), NNRTIs (K101E, K103N/S, G190A/E/S, Y181I/C, Y188H/L) and PIs (M46L, I54V, L76V, V82L/T, N83D, I84V, L90M).

The development of drug resistance mutations K103N Y181C and G190A in long term Nevirapine-containing antiviral therapy.

PMID: 25926857 2014 AIDS research and therapy

Result: The research of Jiong Wang stated that mutation K101E + G190S replicate better with NNRTI drug.

Discussion: It is true that G190A alone can reduce viral fitness, but another research of Jiong Wang found that the variant with K101E + G190S replicated better in the presence of NNRTIs than in the absence of drug, it indicate that mutation K101E may have some effect on the mutant of Codon 190 to enhance the viral fitness.

Discussion: The rank of fitness among mutant viruses was as follows: wild type (WT) >= Y181C >= K103N >= G190A >= V106A >=

PMID: 23361642 2013 The Journal of antimicrobial chemotherapy

Abstract: We studied the primary rilpivirine RAMs (K101E/P, E138A/G/K/Q/R, V179L, Y181C/I/V, H221Y, F227C and M230I/L) and other potential rilpivirine-associated mutations (V90I, L100I, K101T, E138S, V179D/I, Y188L, V189I, G190A/E/S and M230V).

HIV-1 drug resistance and associated factors among adults failing first-line highly active antiretroviral therapy in Ho Chi Minh City, Vietnam.

PMID: 23372113 2013 HIV clinical trials

Abstract: Among 87 participating individuals with VL >=1,000 copies/mL, 11 people still harbored a wild-type strain, while 76 participants harbored a HIV-1 drug-resistant strain (2 of which were against protease inhibitors); common DRMs were M184I/V (74%), Y181I/C/V (39%), G190A/S (32%), T215Y/F (32%), and K103N (31%).