literature

HIV mutation literature information.

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Abstract: RESULTS: Prevalence of SDRMs in drug-naive and treatment-failing patients were linearly correlated, but some SDRMs were classified as outliers - above (PRO: D30N, N88D/S, L90 M, RT: G190A/S/E) or below (RT: M184I/V) expectations.

Result: For NNRTIs, Y181C/I/V was below the CI and G190A/E/S was above the CI in both cohorts.

Result: Highest transmission ratios were observed for N83D (0.165), N88D/S (0.134) and D30N (0.130) for protease

Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.

PMID: 25711326 2015 HIV medicine

Abstract: The most frequent TDR mutations observed were M41L, D67N/G/E, T215F/Y/I/S/C/D/E/V/N, 219Q/E/N/R, K103N/S, and G190A/S/E in reverse transcriptase, and M46I/L and L90M in protease.

Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.

PMID: 25754408 2015 Journal of medical virology

Result: The most prevalent NNRTI mutations were Y181C/I/V (n = 24, 35%), (n = 3, 4%), and (n = 1 (1%), respectively, K103N/S (n = 21 (32%) and n = 1 [1%]),

Discussion: The most prevalent NNRTI mutations were Y181C/I/V (41%), G190A/S/E (34%), K103N/S (32%), and Y188L (7%).

Discussion: These results are of particular relevance as Y181C/I/V and Y188L (and to a lesser extent, G190A/S/E) renders second-generation NNRTI drugs (e.g., ETR, RPV) ineffectual for potential salvage therapies.

Distinct drug resistance profile of HIV-1 subtype A strain circulating in Georgia.

PMID: 25879553 2015 Georgian medical news

Abstract: Frequent co-occurrence of G190S with Y181C and K101E may limit the use of novel generation NNRTIs in subtype A infected patients with previous exposure to this drug class.

Abstract: High prevalence of G190S and K101 mutations suggests subtype A specific response to currently approved first-line NNRTIs.

Abstract: In 69 samples G190S co-occurred with either K101E or Y181C or with both: 39 genotypes G190S/K101E; 10 genotypes G190S/Y181CI and 20 genotypes G190S/

PMID: 26021068 2015 Voprosy virusologii

Abstract: Among the main drug resistance mutations for the entire period of observation was a high frequency of the occurrence M184V mutation, K101E, K103N, Y181C, and G190S influencing the development of the HIV resistance to nucleoside and non-nucleoside reverse transcriptase inhibitors.

The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.

PMID: 26543866 2015 BioMed research international

Result: At the time of the analysis, K103N (p < 0.001) and P225H (p = 0.037) were associated with the first regimen failure, while G190S (p = 0.013) and M230L (p = 0.008) were associated with the second failure.

Discussion: M230L alone produces moderate resistance to ETR, while G190S requires at least another mutation of equal weight to establish resistance.

Discussion: Although our patients did not use the second-generation NNRTI, etravirine (ETR), cross-resistance to this drug was significant in regimens of second failure (31.9%), associated with G190S and M230L mutations.

HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.

PMID: 26717411 2015 PloS one

Result: K103S, V106M, Y188L and G190S/E accounted for most of the remaining transmitted major NNRTI DRMs in LMICs.

Result: Y188L and G190S were the most common major non-tier 1 NNRTI DRMs associated with ADR on a first-line NRTI/NNRTI-containing regimen and among the most common non-tier 1

Result: The two next most common NNRTI DRMs:Y188L and G190S -accounted for an additional 5.7% of viruses with acquired intermediate or high-level NNRTI resistance.

HIV-1 subtype characteristics of infected persons living in southwestern Greece.

PMID: 26715861 2015 HIV/AIDS (Auckland, N.Z.)

Result: The 22 cases experiencing virologic failure presented with the following DRMs: M46I, F53LY, I54LTV, G73ST, L76V, V82AT, I84V, I185V, N88D, and L90M for PIs; L100I, K103NS, V179F Y181C, G190AS, V106A, K103N, and P225H for NNRTIs; and

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Table: G190S

Prevalence and patterns of drug-resistance mutations among HIV-1 patients infected with CRF07_BC strains in Sichuan province, China.

PMID: 25160759 2014 Virologica Sinica

Abstract: The most common mutation in the ART-failure group was M184V (35.88%), K103N (45.01%), Y181C (17.33%), and G190S/A (15.88%).