Abstract: M184V/I, K103N/S, and G190A/S/E were the most common mutations detected.
Result: The most common mutations were M184V/I (45; 53.6%), K103N/S (41; 48.8%), and G190A/S/E (20; 23.8%).
Discussion: M184V/I, K103N/S, and G190A/S/E were the most common mutations detected among those patients.
Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.
PMID: 31430369
2019
The Journal of antimicrobial chemotherapy
Method: Primary NNRTI-R substitutions were L100I, K101E/P, K103N/S, V106M/A, V108I, E138A/G/K/Q/R, V179L, Y181C/I/V, Y188C/H/L, G190A/E/Q/S, H221Y, P225H, F227C and M230L/I in RT.
Table: G190A/E
HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting.
PMID: 31117863
2019
Journal of the International Association of Providers of AIDS Care
Table: G190E
Prevalence of predicted resistance to doravirine in HIV-1-positive patients after exposure to non-nucleoside reverse transcriptase inhibitors.
PMID: 30769200
2019
International journal of antimicrobial agents
Abstract: High-level DOR resistance was defined as detection of any of Y188L, M230L, G190E, V106A/M+F227L, and V106A/M+L234I.
High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014.
PMID: 30640198
2019
The Pediatric infectious disease journal
Result: The most frequent mutations observed were K103N/S (48.0%), M184V (37.5%), G190A/S/E/Q/R (15.1%), and Y181C/G/V (13.8%) (Table 1).
HIV-genetic diversity and drug resistance transmission clusters in Gondar, Northern Ethiopia, 2003-2013.
Result: Taken together, the G190A/S/E mutations were most prominent (seven of the 12 NNRTI mutations), followed by the K103N, Y181I/C and K101E substitutions (two, two and one, respectively).
Table: G190E
Patterns of emergent resistance-associated mutations after initiation of non-nucleoside reverse-transcriptase inhibitor-containing antiretroviral regimens in Taiwan: a multicenter cohort study.
Abstract: The most common emergent RAMs to NRTIs were M184V/I (42.3%) and K65R (28.2%), and those to nNRTIs were Y181C (42.3%), K103N (15.5%),
Result: Of the emergent RAMs to NRTIs, M184V/I (42.3%) and K65R (28.2%) were the most common; and of those RAMs to nNRTIs, Y181C (42.3%) and K103N (15.5%) were the most common, followed by G190A/E/Q (12.7%) and V179D/E (12.7%), and V108I (9.9%) (Figure 2).
Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.
PMID: 29977795
2018
African journal of laboratory medicine
Result: Other NNRTI mutations, such as V90I, K103N, V106A/M, E138A, V179E, Y181C, Y188C/L and G190E were also found in one or two samples.
Table: G190E
Discussion: The mutations K101E, K103N, V106A/M, V179D/T, Y181C, G190A/E and H221Y to NNRTI were the most common minority mutations detected in these patients.
HIV-1C proviral DNA for detection of drug resistance mutations.
Result: G190A, E138A/G) were found concurrently both in viral RNA and proviral DNA, in two patients resistance mutations (M46I and G190E) were detected only in viral RNA, and in five patients archived transmitted drug resistance mutations (M230I, G73S, M184I, M46I, and A62V) in proviral DNA were identified.
Table: G190E
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014.
Discussion: Drug-specific NNRTIs mutations such as: V179E, K238N and G190E were associated with the selection in patients receiving Nevirapine (NVP) and Efavirenz (EFV) according to Stanford HIVdb program.
Discussion: If we assume that most of the HIV infected donors were not aware of the infection status at donation and didn't receive HIV ART, then some DRMs observed in the present study could be transmitted from the treated HIV infected population, especially for the donor with high drug resistance to NNRTIs due to mutations of G190E and E138A.This hypothesis is yet to be confirmed with mo
HIV mutation literature information.
PMID: 
2019
Oman medical journal
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