literature

HIV mutation literature information.

HIV-1 subtype characteristics of infected persons living in southwestern Greece.

PMID: 26715861 2015 HIV/AIDS (Auckland, N.Z.)

Result: The 22 cases experiencing virologic failure presented with the following DRMs: M46I, F53LY, I54LTV, G73ST, L76V, V82AT, I84V, I185V, N88D, and L90M for PIs; L100I, K103NS, V179F Y181C, G190AS, V106A, K103N, and P225H for NNRTIs; and

Lack of integrase inhibitors associated resistance mutations among HIV-1C isolates.

PMID: 26626277 2015 Journal of translational medicine

Result: As previously reported in this group of well characterized patients, two patients had NNRTI associated mutations (G190A and E138G) and one patient had a NRTI resistance-associated mutation (L210 W).

Table: G190A

Outcome of patients on second line antiretroviral therapy under programmatic condition in India.

PMID: 26572102 2015 BMC infectious diseases

Result: 81.25 % (n = 13) had more than 1 NNRTI mutation.Y181C and G190A was the most common NNRTI mutation present in 37.5 % (n = 6) patient each.

Table: G190A

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Result: All the viruses in the cluster carried the G190A mutation (Fig 1A).

Table: G190A

Low Incidence of HIV-1C Acquired Drug Resistance 10 Years after Roll-Out of Antiretroviral Therapy in Ethiopia: A Prospective Cohort Study.

PMID: 26512902 2015 PloS one

Abstract: The NNRTIs resistance associated mutations were K103N (n = 2), V106M, Y181S, Y188L, V90I, K101E and G190A (n = 1 each).

Result: Other NNRTIs associated mutations Y181S, Y188L, V90I, K101E and G190A were observed in one patient each.

Table: G190A

Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.

PMID: 26469189 2015 PloS one

Result: Twenty-eight NVP-selected mutations (V90I, K101E, K103N/R, V106A/I/M, V108I, E138A/G/K/R, Y181C, Y188C, G190A or P225H) were detected in 19 samples at levels of 1.1% to 99.1%.

Table: G190A

Table: G190G/A

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Abstract: RESULTS: Prevalence of SDRMs in drug-naive and treatment-failing patients were linearly correlated, but some SDRMs were classified as outliers - above (PRO: D30N, N88D/S, L90 M, RT: G190A/S/E) or below (RT: M184I/V) expectations.

Result: For NNRTIs, Y181C/I/V was below the CI and G190A/E/S was above the CI in

Discussion: Our results are consistent with other studies: M184I/V has been shown to have low persistence after transmission to drug-naive patients; G190A has been shown to have high persistence.

Frequency of transmitted drug resistance mutations among treatment-naive HIV-1-infected individuals at a tertiary care centre in South India.

PMID: 26296335 2015 Molecular diagnosis & therapy

Abstract: Based on the CPR tool, three strains (2.4 %) had TDRMs, and these were K101E, Y181C and G190A.

Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.

PMID: 26161559 2015 PloS one

Method: A NVP RAM was considered if at least one of the following genetic changes in reverse

Result: Of these, the most frequent mutations were K103N (n = 16, 24.2%, 95% CI 13.4-34.6) and Y181C (n = 15, 22.7%, 95% CI 12.6-32.8), and G190A (n = 10, 15.2%, 95% CI 6.5-23.8).

Result: The NNRTI RAM most frequently represented in this ARV class were K103N (n = 16, 21.6%, 95% CI 12.2-31.0) and Y181C (n = 15, 20.3%, 95% CI 11.1-29.4) and G190A (n = 10, 13.5%, 95% CI 5.7-21.3).

Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.

PMID: 26107265 2015 PloS one

Table: G190A

Table: G190G/A

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