literature

HIV mutation literature information.

Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.

PMID: 26010948 2015 PloS one

Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and to PIs (D30N, M46I/L, I54V/T, L76V, V82A, I84V, N88D

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.

PMID: 26038551 2015 Proc Natl Acad Sci U S A

Abstract: Three compounds were found to inhibit RNA- and DNA-dependent DNA polymerase activity of HIV-1 RT in the micromolar range while retaining potency against RT variants carrying one of three major NNRTI resistance mutations: K103N, Y181C, or G190A.

The prevalence and determinants of drug-resistance-associated mutations in the HIV-1-infected MSM population of Henan Province in China.

PMID: 26077516 2015 Archives of virology

Abstract: After antiretroviral therapy (ART), the frequencies of K103N, G190A, Y181C, and V106A mutations were highly elevated.

Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.

PMID: 26107265 2015 PloS one

Table: G190A

Table: G190G/A

Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.

PMID: 26161559 2015 PloS one

Method: A NVP RAM was considered if at least one of the following genetic changes in reverse

Result: Of these, the most frequent mutations were K103N (n = 16, 24.2%, 95% CI 13.4-34.6) and Y181C (n = 15, 22.7%, 95% CI 12.6-32.8), and G190A (n = 10, 15.2%, 95% CI 6.5-23.8).

Result: The NNRTI RAM most frequently represented in this ARV class were K103N (n = 16, 21.6%, 95% CI 12.2-31.0) and Y181C (n = 15, 20.3%, 95% CI 11.1-29.4) and G190A (n = 10, 13.5%, 95% CI 5.7-21.3).

Frequency of transmitted drug resistance mutations among treatment-naive HIV-1-infected individuals at a tertiary care centre in South India.

PMID: 26296335 2015 Molecular diagnosis & therapy

Abstract: Based on the CPR tool, three strains (2.4 %) had TDRMs, and these were K101E, Y181C and G190A.

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Abstract: RESULTS: Prevalence of SDRMs in drug-naive and treatment-failing patients were linearly correlated, but some SDRMs were classified as outliers - above (PRO: D30N, N88D/S, L90 M, RT: G190A/S/E) or below (RT: M184I/V) expectations.

Result: For NNRTIs, Y181C/I/V was below the CI and G190A/E/S was above the CI in

Discussion: Our results are consistent with other studies: M184I/V has been shown to have low persistence after transmission to drug-naive patients; G190A has been shown to have high persistence.

Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.

PMID: 26469189 2015 PloS one

Result: Twenty-eight NVP-selected mutations (V90I, K101E, K103N/R, V106A/I/M, V108I, E138A/G/K/R, Y181C, Y188C, G190A or P225H) were detected in 19 samples at levels of 1.1% to 99.1%.

Table: G190A

Table: G190G/A

Low Incidence of HIV-1C Acquired Drug Resistance 10 Years after Roll-Out of Antiretroviral Therapy in Ethiopia: A Prospective Cohort Study.

PMID: 26512902 2015 PloS one

Abstract: The NNRTIs resistance associated mutations were K103N (n = 2), V106M, Y181S, Y188L, V90I, K101E and G190A (n = 1 each).

Result: Other NNRTIs associated mutations Y181S, Y188L, V90I, K101E and G190A were observed in one patient each.

Table: G190A

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Result: All the viruses in the cluster carried the G190A mutation (Fig 1A).

Table: G190A

Browser Board

Co-occurred Entities

Filtrator