Drug resistance is widespread among children who receive long-term antiretroviral treatment at a rural Tanzanian hospital.
PMID: 20576637
2010
The Journal of antimicrobial chemotherapy
Abstract: The most frequent mutations were M184V (n = 11), conferring resistance to lamivudine and emtricitabine, and Y181C (n = 4), G190A/S (n = 4) and K103N (n = 4), conferring resistance to NNRTIs.
Result: The most frequent RT mutations were M184V (n = 11), conferring resistance to lamivudine and emtricitabine, and Y181C (n = 4), G190A/S (n = 4) and K103N (n = 4), conferring resistance to NNRTIs.
Table: G190A
Virologic and immunologic outcomes in HIV-infected Cambodian children after 18 months of highly active antiretroviral therapy (HAART).
PMID: 20578491
2010
The Southeast Asian journal of tropical medicine and public health
Abstract: Genotypic resistance typing in 2 children with PVL > 400 copies/ml at 18 months demonstrated mutations associated with resistance to lamivudine (M184V) and non-nucleoside reverse transcriptase inhibitors (Y181C and G190A).
Result: However, mutations associated with resistance to lamivudine (M184V) and to non-nucleoside reverse transcriptase inhibitors (Y181C and G190A) were detected in samples collected from both children at 18 months.
Discussion: Resistance genotyping performed in 2 of these patients demonstrated mutations associated with resistance to lamivudine (M184V) and to non-nucleoside reverse transcriptase
Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.
Abstract: K103N and Y181C mutants had normal RNase H activity; V106A, G190A, and G190S mutants had moderate reductions in activity; and the P236L mutant had substantially reduced activity.
Abstract: K103N and Y181C viruses had fitness similar to that of the wild type while V106A, G190A, G190S, and P236L viruses had reduced fitness.
Abstract: We measured the fitness of six NNRTI-resistant mutants, the K103N, V106A, Y181C
Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.
Introduction: This region includes the following important and well-defined drug resistance mutations to nucleoside RT inhibitors (NRTIs) and non-nucleoside RT inhibitors (NNRTIs): L210W, T215Y/F and K219Q/E associated with resistance to zidovudine (AZT) and stavudine (d4T); M184I/V associated with resistance to lamivudine (3TC) and emtricitabine (FTC); and Y181C/I/V, Y188C/L/H and G190S/A associated with resistance to nevirapine (NVP), efavirenz (EFV) and etravirin (ETR).
Result: None of the five
Table: G190A
Estimating frequencies of minority nevirapine-resistant strains in chronically HIV-1-infected individuals naive to nevirapine by using stochastic simulations and a mathematical model.
Abstract: Here, we employ stochastic simulations and a mathematical model to estimate the frequencies of strains carrying different combinations of the common nevirapine resistance mutations K103N, V106A, Y181C, Y188C, and G190A in chronically infected HIV-1 patients naive to nevirapine.
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
PMID: 20805392
2010
Antimicrobial agents and chemotherapy
Abstract: With efavirenz (EFV), F227C and V106M were the major mutations responsible for viral breakthrough in subtype A viruses, whereas a single pathway (G190A/V106M) accounted for mutation development in subtype C viruses.
Frequency and diversity of human immunodeficiency virus type 1 mutations associated with antiretroviral resistance among patients from Southern Brazil failing highly active antiretroviral therapy (HAART).
PMID: 20818500
2010
International journal of molecular medicine
Abstract: The most frequent major mutations associated with resistance to non-nucleoside RT inhibitors (NNRTI) were K103N in 47 (37.0%), G190A in 11 (8.7%), and G190S in 2 (2.6%) tests.
Low prevalence of transmitted drug resistance among newly diagnosed HIV-1 patients in Latvia.
Abstract: The K103N substitution also plays an important role in the L74I emergence when not associated with the other non-NRTI mutations seen in this study: L100I, G190A and Y181C.
Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants.
Method: NVP-R was defined by mutations present at the following amino acid sites: L100I, K101E/P, K103N/S, V106A/M, V108I, Y181C/I/V, Y188C/L/H, or G190A/S/E based on recommendations from International AIDS Society-USA Drug Resistance Mutations and Stanford University drug-resistance database.
HIV mutation literature information.
PMID: 
2010
The Journal of antimicrobial chemotherapy
Browser Board
Co-occurred Entities
Filtrator
ViMRT