literature

HIV mutation literature information.

Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017).

PMID: 31922125 2020 EClinicalMedicine

Abstract: One NRTI-associated (M184V/I) and three NNRTI-associated (K103N/S, Y181C/I and G190A/S) mutations had high percentages in ART-naive and ART-treated individuals, and these mutations conferred high-level resistance to 3TC, EFV and/or NVP.

Introduction: In addition, we report high percentages of one NRTI (M184V/I) and three NNRTI (K103N/S, Y181C/I and G190A/S) mutations in ART-naive and ART-treated individuals, which confer high-level resistance to 3TC, EFV and/or NVP.

Discussion: The finding that a

Prevalence of HIV-1 Drug-Resistance Genotypes Among Unique Recombinant Forms from Yunnan Province, China in 2016-2017.

PMID: 31914782 2020 AIDS research and human retroviruses

Abstract: Mutations such as M184V/I (35.4%) in NRTIs and K103N/R/S/T (25.4%), V179D/E/T/Y (18.9%), G190A/E/R/S (13.8%), and Y181C (9.2%) in NNRTIs were common among the HIV-1 URF strains relative to other mutations.

Pretreatment HIV drug resistance spread within transmission clusters in Mexico City.

PMID: 31819984 2020 The Journal of antimicrobial chemotherapy

Result: Other commonly observed NNRTI DRMs included G190A, Y188L, Y181C and K101E (Figure 1c).

Evaluation of the management of pretreatment HIV drug resistance by oligonucleotide ligation assay: a randomised controlled trial.

PMID: 31818716 2020 The lancet. HIV

Abstract: The OLA-guided therapy group had pre-ART peripheral blood mononuclear cells evaluated for drug resistance to non-nucleoside reverse transcriptase inhibitor (NNRTI) at codons Lys103Asn, Tyr181Cys, Gly190Ala, and to lamivudine at Met184Val, and when at least one drug-resistant codon was detected in a participant's pre-ART specimen, clinicians were directed to prescribe protease inhibitor-based second-line ART.

Method: Peripheral blood mononuclear cells were evaluated for NNRTI and NRTI drug resistance mutations, K103N, Y181C, G190A, and

Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.

PMID: 31774913 2020 The Journal of infectious diseases

Result: The following NNRTI mutations were also associated: A98G, L100I, K103R, V108I, Y181C, Y188L, G190A, P225H, L228R, and M230L.

Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia.

PMID: 31754119 2019 Scientific reports

Result: Also, one Croatian patient with a complex pattern of resistance (SDRM to PI: I84V + NRTI: M184MIV, T215S, L210W + NNRTI: K101E, Y181C, G190A, P225PH) was observed in a transmission pair with a Serbian sequence with a similar SDRM pattern with one additional SDRM (PI: M46I), indicating cross border transmission of multi-class drug resistance.

Result: Some of these sequences carrying SDRMs: T69D, G190E, K219Q

Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon.

PMID: 31751428 2019 PloS one

Result: The most resistance NNRTI-associated pattern was G190A-Y181C which showed HLR to all the drugs in the class and this was from an ART-naive patient (Table 3).

Table: G190A

HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review.

PMID: 31745412 2019 Oman medical journal

Abstract: M184V/I, K103N/S, and G190A/S/E were the most common mutations detected.

Result: The most common mutations were M184V/I (45; 53.6%), K103N/S (41; 48.8%), and G190A/S/E (20; 23.8%).

Discussion: M184V/I, K103N/S, and G190A/S/E were the most common mutations detected among those patients.

[Postmortem Molecular Epidemiology of HIV-1 Strains Isolated in Turkey].

PMID: 31709935 2019 Mikrobiyoloji bulteni

Abstract: Detected mutations were as follows: M41L, T215C, K65R, M184V, responsible for nucleoside reverse transcriptase inhibitor (NRTI) resistance; K103N, Y181C, G190A, responsible for non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance; D30N, M46I, responsible for protease inhibitor (PI) resistance.

HIV Drug Resistance after Failure of 6 Month First-line Therapy in a Hospital: A Case Series.

PMID: 31699949 2019 Acta medica Indonesiana

Abstract: The common NRTI mutations were M184VI and K65R, while NNRTI mutations were Y181CFGVY, K103N, A98AG, E138GQ and G190AGS.

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