Virologic suppression in response to antiretroviral therapy despite extensive resistance within HIV-1 reverse transcriptase after the first virologic failure.
Discussion: However, some studies have shown that NVP-containing ARVs have repercussions on the response to etravirine for selecting the Y181C and G190A mutations, whereas the K103 mutation associated with EFV does not interfere with etravirine susceptibility.
HIV-genetic diversity and drug resistance transmission clusters in Gondar, Northern Ethiopia, 2003-2013.
Abstract: One cluster was associated with the G190A mutation and showed onward transmissions at high rate.
Discussi
Discussion: An association between clustering and increased transmission of viruses harbouring NNRTI DRMs, including the G190A DRM found here, has been described in Quebec, Canada.
Discussion: Importantly, we show that the G190A mutation has spread in Gondar by rapid transmission within local clusters.
Discussion: In the present study, we identified one cluster with the G190A mutation with onward transmissions of this DRM for at least 8 years (2003-2010).
Discussion: The G190A mutation represents a slowly reverting HIVDR mutation and when such mutations are present in a population with frequent transmission it might persist and expand.
HIV-1C proviral DNA for detection of drug resistance mutations.
Abstract: While mutations G190A and E138A were concurrently found in both compartments, others such as G73S on PR and A62V, Result: G190A, E138A/G) were found concurrently both in viral RNA and proviral DNA, in two patients resistance mutations (M46I and G190E) were detected only in viral RNA, and in five patients archived transmitted drug resistance mutations (M230I, G73S, M184I, M46I, and A62V) in proviral DNA were identified.
Table: G190A
Human immunodeficiency virus type 1 drug resistance in a subset of mothers and their infants receiving antiretroviral treatment in Ouagadougou, Burkina Faso.
PMID: 30079168
2018
Journal of public health in Africa
Result: G190A and K101Q/E were more frequent in mothers (16.67% and 16.67% respectively) than in infants (5.56% and 5.56%) and conferred resistance to NVP and EFV.
Discussion: Mutations Y181C, G190A conferred high resistance to EFV and NVP in mothers and infants.
Discussion: Other studies reported mutations G190A, Y181C that conferred high resistance to NNRTI in individuals with subtype C.
Antiretroviral resistance among HIV-1 patients on first-line therapy attending a comprehensive care clinic in Kenyatta National Hospital, Kenya: a retrospective analysis.
PMID: 30061964
2018
The Pan African medical journal
Abstract: They included K103N (n = 10), G190A (n = 1), Y181C (n = 1) and Y188L (n = 1).
Result: They included K103N (n=10), G190A (n=1), Y181C (n=1) and Y188L (n=1) (Table 2).
Table: G190A
Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.
PMID: 29977795
2018
African journal of laboratory medicine
Result: Among the minority NNRTI mutations, V108I, V179T were detected in four samples and G190A, H221Y and K101E were detected in three samples.
Result: From the 1% mixed clone, K103N was not detected within the 520 sequence reads; Y181C and M184V were detected at the level of 1.03% with 1335 reads, while G190A was detected at 0.97% with 785 reads.
Result: The common minority NNRTI mutations detected were V106M, V179T and G190A (3/20 each), followed by E138
Patterns of emergent resistance-associated mutations after initiation of non-nucleoside reverse-transcriptase inhibitor-containing antiretroviral regimens in Taiwan: a multicenter cohort study.
Abstract: The most common emergent RAMs to NRTIs were M184V/I (42.3%) and K65R (28.2%), and those to nNRTIs were Y181C (42.3%), K103N (15.5%),
Result: Of the emergent RAMs to NRTIs, M184V/I (42.3%) and K65R (28.2%) were the most common; and of those RAMs to nNRTIs, Y181C (42.3%) and K103N (15.5%) were the most common, followed by G190A/E/Q (12.7%) and V179D/E (12.7%), and V108I (9.9%) (Figure 2).
High prevalence of HIV-1 transmitted drug resistance among therapy-naive Burmese entering travelers at Dehong ports in Yunnan, China.
Discussion: The major TDRMs observed in this study have been reported in a previous study of HIV Drug Resistance among ART-failure individuals in Yunnan Province, which figured out mutations such as M184 V/I, K103 N, V106A, Y181C and G190A were common.
Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort.
Method: Plasma samples contained a median of 3 [Q1-Q3: 2-4] NNRTI-associated drug resistance mutations which included A98G, L100I, K101E/H, K103N/S, V106M, V108I, E13
Result: No other RPV-associated mutations in this sample set including K101E, E138A/K, V179I/L, Y188L, G190A, M230L, H221Y or F227C were associated with RPV cross-resistance (Table 2).
HIV mutation literature information.
PMID: 
2018
BMC infectious diseases
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