Prevalence of genotypic resistance to nucleoside analogues, nonnucleoside analogues, and protease inhibitors in HIV-infected persons in Athens, Greece.
PMID: 18275347
2008
AIDS research and human retroviruses
Abstract: The most prevalent mutations related to NNRTIs were K103N [present in 59 tests (25.2%)], G190A [50 (21.4%)], and Y181C [48 (20.5%].
Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability.
Abstract: We found that the mutations K101A, P225H, Y318F and Y318W decreased RT heterodimer stability whereas K103N, V108I, V108W, Y181C, Y188L, G190A, G190E, G190W and P225W increased RT heterodimer stability.
Nevirapine resistance in women and infants after first versus repeated use of single-dose nevirapine for prevention of HIV-1 vertical transmission.
PMID: 18582198
2008
The Journal of infectious diseases
Method: The assay cutoff for mutation detection was 0.5% for K103N and G190A, and 1.0% for Y181C.
Result: Infant samples from 6 weeks of age were also analyzed using the LigAmp assay to detect and quantify K103N, Y181C, and G190A.
Result: The mutations detected by LigAmp were present at levels less than 10% with one exception: G190A was detected at 60% in one infant.
Table: G190A
Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region.
Abstract: Human immunodeficiency virus type 1 clones containing Delta 69 in a multidrug-resistant sequence background, including the Q151M complex and substitutions K103N, Y181C, M184V, and G190A, showed high-level resistance to all tested nucleoside RT inhibitors.
HIV drug resistance pattern among HAART-exposed patients with suboptimal virological response in Ouagadougou, Burkina Faso.
PMID: 18667925
2008
Journal of acquired immune deficiency syndromes (1999)
Abstract: Dominant mutations included M46I (37%), 154V (26%), V82A/T/F (30%) in PR; K103N (44%), G190A/S (16%) and T215F/Y (48%) (NRTIs) in RT.
Prevalence and risk factors for etravirine resistance among patients failing on non-nucleoside reverse transcriptase inhibitors.
Abstract: The most frequent mutations were G190A (230%), Y181C (23%) and K101E (14.1%).
Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-Dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission.
PMID: 18684096
2008
The Journal of infectious diseases
Abstract: METHODS: We tested plasma HIV by using a genotyping assay (ViroSeq; Celera Diagnostics), a phenotypic resistance assay (PhenoSense; Monogram Biosciences), and sensitive point mutation assay (LigAmp, for K103N, Y181C, and G190A).
Method: PCR products generated in the ViroSeq system were also analyzed using the LigAmp assay to detect and quantify HIV variants with NVP resistance mutations (K103N=AAC, 0.5% assay cutoff; Y181C=TGT, 1% assay cutoff; G190A=GCA, 0.5% assay cutoff).
Table: G190A
Figure: Panel D: Portion of late-infected infants with NVP resistance mutations (K103N, Y181C, or G190A) detected by the LigAmp a
The impacts of current antiretroviral therapy regimens on Chinese AIDS patients and their implications for HIV-1 drug resistance mutation.
PMID: 18806342
2008
Japanese journal of infectious diseases
Abstract: The most common mutations conferring resistance to NNRTIs were K103N, Y181C and G190A, representing 56.5, 30.4 and 14.5%, respectively.
Evaluating the role of etravirine in the second-line antiretroviral therapy after failing an initial non-nucleoside reverse transcriptase inhibitor-based regimen in a resource-limited setting.
HIV mutation literature information.
PMID: 
2008
AIDS research and human retroviruses
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