Abstract: One NRTI-associated (M184V/I) and three NNRTI-associated (K103N/S, Y181C/I and G190A/S) mutations had high percentages in ART-naive and ART-treated individuals, and these mutations conferred high-level resistance to 3TC, EFV and/or NVP.
Introduction: In addition, we report high percentages of one NRTI (M184V/I) and three NNRTI (K103N/S, Y181C/I and G190A/S) mutations in ART-naive and ART-treated individuals, which confer high-level resistance to 3TC, EFV and/or NVP.
Discussion:
Prevalence of HIV-1 Drug-Resistance Genotypes Among Unique Recombinant Forms from Yunnan Province, China in 2016-2017.
PMID: 31914782
2020
AIDS research and human retroviruses
Abstract: Mutations such as M184V/I (35.4%) in NRTIs and K103N/R/S/T (25.4%), V179D/E/T/Y (18.9%), G190A/E/R/S (13.8%), and Y181C (9.2%) in NNRTIs were common among the HIV-1 URF strains relative to other mutations.
Pretreatment HIV drug resistance spread within transmission clusters in Mexico City.
PMID: 31819984
2020
The Journal of antimicrobial chemotherapy
Result: Other commonly observed NNRTI DRMs included G190A, Y188L, Y181C and K101E (Figure 1c).
Evaluation of the management of pretreatment HIV drug resistance by oligonucleotide ligation assay: a randomised controlled trial.
Abstract: The OLA-guided therapy group had pre-ART peripheral blood mononuclear cells evaluated for drug resistance to non-nucleoside reverse transcriptase inhibitor (NNRTI) at codons Lys103Asn, Tyr181Cys, Gly190Ala, and to lamivudine at Met184Val, and when at least one drug-resistant codon was detected in a participant's pre-ART specimen, clinicians were directed to prescribe protease inhibitor-based second-line ART.
Method: Peripheral blood mononuclear cells were evaluated for NNRTI and NRTI drug resistance mutations, K103N, Y181C, G190A, and
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.
PMID: 31774913
2020
The Journal of infectious diseases
Result: The following NNRTI mutations were also associated: A98G, L100I, K103R, V108I, Y181C, Y188L, G190A, P225H, L228R, and M230L.
Analysis of HIV-1 diversity, primary drug resistance and transmission networks in Croatia.
Result: Also, one Croatian patient with a complex pattern of resistance (SDRM to PI: I84V + NRTI:
Result: Some of these sequences carrying SDRMs: T69D, G190E, K219Q and K219R + M41L belonged to large TCs (Table 3), others were not part of TCs, such as SDRMs K103N, G140A, G190A and M41L + T215D, while the sequence with SDRMs T215D + L210W formed a transmission pair with a Croatian sequence from the previous dataset (2006-2008) that carried the same resistance pattern.
Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon.
Result: The most resistance NNRTI-associated pattern was G190A-Y181C which showed HLR to all the drugs in the class and this was from an ART-naive patient (Table 3).
Table: G190A
HIV Drug Resistance among Patients Failing Therapy at a Tertiary Center in Oman: A Case Record Review.
HIV mutation literature information.
PMID: 
2020
EClinicalMedicine
Browser Board
Co-occurred Entities
Filtrator
ViMRT