Method: Four G190A isolates from a large transmission cluster (n=27), (GenBank accession numbers EU375798-EU375801), were assessed for baseline susceptibility to nevirapine (NVP), efavirenz (EFV), etravirine (ETV) and TMC-120.
Result: K103N, V108I, G190A, associated with resistance to NNRTIs.
Result: All 27 patients harboured the G190A and A98S mutations.
Result: Such forward transmission of NNRTI resistance in clusters was independent of the G190A mutation (Fig, 1).
Successful application of laboratory tools for the detection of HIV drug resistance in routine clinical care in Georgia.
Abstract: RESULTS: Direct sequencing of DNA provirus disclosed key mutations (such as G190A/S, V106A, K103N and T215F) to RT inhibitors more frequently (7 patients out 31) than in plasma RNA (2 out of 31).
Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region.
Abstract: In this work, we have measured the in vivo fitness of HIV-1 variants containing a deletion of 3 nucleotides affecting codon 69 (Delta69) of the viral RT as well as the replication capacity (RC) ex vivo of a series of recombinant HIV-1 variants carrying an RT bearing the Delta69 deletion or the T69A mutation in a multidrug-resistant (MDR) sequence background, including the Q151M complex and substitutions M184V, K103N, Y181C, and G190A.
Molecular epidemiology of HIV type 1 in treatment-naive patients in north Ethiopia.
PMID: 17451346
2007
AIDS research and human retroviruses
Abstract: Two patients (2.2%) had the G190A mutation, which confers resistance to the nonnucleoside reverse transcriptase inhibitor, nevirapine.
HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
Method: NNRTI-selected mutations included A98G, L100I, K101E/P/N/H, K103N/S, V106A/M, V108I, V179D/E, Y181C/I/V, Y188L/C/H, G190A/S/E/Q, P225H, F227L, M230L, P236L, and K238T.
NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.
Abstract: High-level resistance to nevirapine and moderate level resistance to both stavudine and zidovudine were associated with G190S/A/E substitutions.
Abstract: Recombinant HIV-1 strains carrying G190S/A/E, G190S+T215Y, T215Y and K103N mutations were constructed to evaluate susceptibility to both NNRTIs and nucleoside RT inhibitors (NRTIs).
Genotypic drug resistance and long-term mortality in patients with triple-class antiretroviral drug failure.
Abstract: In a regression model adjusted for CD4+ T-cell count, HIV RNA, year of TCF, age, gender and previous inferior antiretroviral therapy, harbouring > or =9 versus < or =8 mutations was associated with increased mortality (mortality rate ratio [MRR] 2.3 [95% confidence interval (CI) 1.1-4.8]), as were the individual mutations T215Y (MRR 3.4 [95% CI 1.6-7.0]), G190A/S (MRR 3.2 [95% CI 1.6-6.6]) and V82F/A/T/S (MRR 2.5 [95% CI 1.2-5.3]).
N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.
Result: N348I was highly associated with several key drug resistance mutations, including M184V/I (p = 6.6 x 10-45) the TAMs M41L (p = 1.8 x 10-14), D67N (p = 7.7 x 10-10), K70R (p = 1.4 x 10-10), T215Y/F (p = 6.0 x 10-21), K219Q/E (p = 8.0 x 10-4), and L210W (p = 0.002), and the NNRTI resistance mutations K103N (p = 1.1 x 10-19), V108l (p = 8.4 x 10-13), Y181C/I (p = 4.7 x 10-13) and G190A/S (p = 8.0 x 10-9) (Figure 1).
Discussion: In our cohort N348I was associated with the appearance of
HIV mutation literature information.
PMID: 
2008
AIDS (London, England)
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