literature

HIV mutation literature information.

Primary resistance to integrase strand transfer inhibitors in Spain using ultrasensitive HIV-1 genotyping.

PMID: 32929472 2020 The Journal of antimicrobial chemotherapy

Abstract: Only three (1.7%) subjects had INSTI TDR (R263K, E138K and G163R), while minority variants with integrase TDR were detected in 9.6% of subjects.

Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda.

PMID: 32853364 2020 The Journal of antimicrobial chemotherapy

Abstract: Two patients, one with E138A/G140A/Q148R/G163R and one with E138K/G140A/S147G/Q148K, displayed the highest reported resistance to raltegravir, elvitegravir and even dolutegravir.

Prevalence of HIV-1 Integrase Strand Transfer Inhibitor Resistance in Treatment-Naive Voluntary Counselling and Testing Clients by Population Sequencing and Illumina Next-Generation Sequencing in Taiwan.

PMID: 33364799 2020 Infection and drug resistance

Abstract: Of the 38 patients diagnosed in 2017 who had both NGS and population sequencing data, none had INSTI resistance-associated mutations by population sequencing; however, NGS detected four more INSTI resistance-associated mutations with low frequencies (G163R 3.25%, S153F 3.21%, S153Y 1.36% and Y143H 2.06%).

Result: Among the 38 patients who had both sanger sequencing and Illumina NGS data, 5% (2/38) had NRTI/NNRTI/PI resistance and none had INSTI resistance (one had an L74V substitution) by sanger sequencing however Illumina NGS for INSTI resistanc

Genetic Features of HIV-1 Integrase Sub-Subtype A6 Predominant in Russia and Predicted Susceptibility to INSTIs.

PMID: 32752001 2020 Viruses

Result: The major mutation, Q146P, was accompanied by the accessory mutation G163R in one patient and by itself in the second patient.

Result: The third patient had only the accessory mutation G163R.

Absence of Integrase Inhibitor-Associated Resistance Among Antiretroviral Therapy-Naive HIV-1-Infected Adults in Guangdong Province, China, in 2018.

PMID: 33324078 2020 Infection and drug resistance

Abstract: Among them, no major resistance mutations to INSTIs were identified, and four accessory mutations, including T97A (0.12%, 1/827), A128T (0.24%, 2/827), E157Q (0.85%, 7/827), and G163R (0.24%, 2/827), were found in twelve individuals.

Abstract: Two patient samples contained the G163R mutation conferring low-level resistance to elvitegravir and raltegravir.

Conclusion: In conclusion, our results demonstrate that drug resistance mutations associated with INSTIs,

Brief Report: Durable Suppression and Low Rate of Virologic Failure 3 Years After Switch to Dolutegravir + Rilpivirine 2-Drug Regimen: 148-Week Results From the SWORD-1 and SWORD-2 Randomized Clinical Trials.

PMID: 32675772 2020 Journal of acquired immune deficiency syndromes (1999)

Discussion: Interestingly, in 1 participant with baseline integrase substitutions N155N/H and G163G/R by proviral DNA genotype assay, only the integrase polymorphism mixture (V151V/I), which is not associated with dolutegravir resistance, was detected at virologic failure.

Variability in HIV-1 Integrase Gene and 3'-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy.

PMID: 32106437 2020 International journal of molecular sciences

Discussion: In fact, computational modeling of INSTIs resistance development across different HIV-1 subtypes showed that compared to subtype B, the presence of M50I in subtypes A and C, L74I in subtypes A and CRF02_AG, G163R in CRF01_AE, and V165I in subtypes F and CRF01_AE would be associated with lower genetic barrier to resistance in these non-B clades.

HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.

PMID: 32041622 2020 AIDS research and therapy

Table: G163R

Occurrence of the S230R integrase strand inhibitor mutation in a treatment-naive individual case report.

PMID: 32629687 2020 Medicine

Conclusion: The genotype resulted at day 15 after antiretroviral therapy was initiated and revealed clade B HIV-1 with G163R and S230R INSTI mutations, the latter present at a detection frequency of 16.2%, reported as conferring low-level DTG resistance.

Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.

PMID: 30380053 2019 The Journal of antimicrobial chemotherapy

Result: Fifteen participants had integrase DRM20% (15/83, 18.1%), including Q148R conferring low-level resistance to dolutegravir, and some accessory integrase mutations were also found: L74I/M (n = 12/15, 80.0%), E157Q (n = 1) and G163R (n = 1).

Result: While no major mutation was described for dolutegravir resistance, we found some accessory integrase mutations in 98/524 (18.7%), such as L74I/M (n = 81/98, 82.7%), T97A (n = 8/98, 8.2%) and E157Q (n = 5/98, 5.1%), and more sporadically E138D/K (n = 2), V151I (n = 1) and G163R

Browser Board

Co-occurred Entities

Filtrator