1Abstract: Viruses containing G118R and E138K remained largely susceptible to both RAL and EVG, suggesting a unique interaction between this second-generation INSTI and the enzyme may be defined by these residues as a potential basis for the increased intrinsic affinity and longer ""off"" rate of MK-2048."
Abstract: G118R also reduced viral replication capacity to approximately 1% that of the isogenic wild-type (wt) virus.
Abstract: G118R, which appeared first in cell culture, conferred low levels of resistance to MK-2048.
Abstract: Here, we report the identification of mutations (G118R and E138K) which confer resistance to MK-2048 and not to RAL or EVG.
HIV mutation literature information.
PMID: 
2010
Journal of virology
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