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 HIV mutation literature information.


  Mechanisms of HIV-1 Nef function and intracellular signaling.
 PMID: 21336563       2011       Journal of neuroimmune pharmacology
Method: As previously discussed subtype E Nefs have arginine at position 191 and introduction of F191R into the subtype B Nef from HIV-1SF2 debilitates PAK2 activation.


  Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.
 PMID: 17881449       2007       Journal of virology
Abstract: Furthermore, the F191H/R changes neither affected the levels of interleukin-2 receptor expression and apoptosis of HIV-1-infected primary T cells nor reduced Nef-mediated induction of NFAT.
Abstract: To further evaluate the role of F191 in Nef function and to elucidate the biological relevance of Nef-PAK2 interaction, we performed a comprehensive analysis of HIV-1 Nef mutants carrying F191H and F191R mutations.
Abstract: Unexpectedly, the F191H change markedly reduced and the F191R mutation disrupted the ability of Nef to enhance virion infectivity in P4-CCR5 indica



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