Abstract: Furthermore, the
F191H/R changes neither affected the levels of interleukin-2 receptor expression and apoptosis of
HIV-1-infected primary T cells nor reduced
Nef-mediated induction of NFAT.
Abstract: To further evaluate the role of F191 in
Nef function and to elucidate the biological relevance of
Nef-PAK2 interaction, we performed a comprehensive analysis of HIV-1
Nef mutants carrying
F191H and
F191R mutations.
Abstract: Unexpectedly, the
F191H change markedly reduced and the
F191R mutation disrupted the ability of
Nef to enhance virion infectivity in P4-CCR5 indica
HIV mutation literature information.
PMID: 
2007
Journal of virology
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