Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea.
PMID: 30229661
2019
AIDS research and human retroviruses
Abstract: In the former group, both major INSTI resistance cases involved the nonpolymorphic E92Q mutation in the integrase strand.
Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes.
Abstract: Some mutations, such as G118R, previously shown to severely impair the replication capacity in vitro, were associated with more sustained virological and immunological benefits of continued DTG therapy, while other mutations, such as E92Q and G140A/Q148K, were associated with more variable outcomes.
Drug resistance emergence in macaques administered cabotegravir long-acting for pre-exposure prophylaxis during acute SHIV infection.
Discussion: Although the in vitro replication capacity mutants containing E92Q or G118R was markedly reduced, their transmission fitness is not known as it is also unknown if their transmission potential may be increased if viremias are high as it is the case of acute HIV infection.
Discussion: It will be important to see if the G118R, G140R and E92Q/G mutations selected in SIV in vivo will also be selected in patients failing CAB-containing regimens, and if these mutations will confer similar levels of drug resistance in HIV.
Discussion: Overall, these results demonstrate intermediate to high-level resistance to CAB and other PMID: 31169022
2019
AIDS research and human retroviruses
Abstract: Prevalence of elvitegravir-associated DRMs T66A/I/K, E92Q, S147G, and the dolutegravir-associated DRM R263K increased.
Delayed linkage to HIV care among asylum seekers in Quebec, Canada.
Result: One newly diagnosed patient, who was unknowingly prescribed functional monotherapy, developed full integrase inhibitor resistance (N155H, Q148R, S147G, E138K, and E92Q mutations).
Kinetics of Archived M184V Mutation in Treatment-Experienced Virally Suppressed HIV-Infected Patients.
PMID: 31430369
2019
The Journal of antimicrobial chemotherapy
Discussion: Additionally, any potential benefit of decreased viral fitness by M184V/I on the efficacy of dolutegravir/lamivudine may not outweigh the risk of virological failure with INSTI-R development, as it is possible for M184V and INSTI-R to co-develop while failing a dolutegravir/lamivudine regimen.In vitro studies further suggest that viral fitness defects can be overcome by drug resistance in the presence of antiretroviral drugs: HIV-1 with M184V and INSTI-R (E92Q, Q148R or N155H) grows more efficiently than WT HIV-1 in the presence of emtricitabine and the INSTI elvitegravir at physiological concentrations.
Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence.
Result: Mutations E92Q and T66K - which are also resistance-related mutations - were not present in frequencies high enough to be considered in the network.
Result: The residue 92, may show the mutation E92Q that was shown to reduce RAL susceptibility.
Switching to bictegravir/emtricitabine/tenofovir alafenamide maintained HIV-1 RNA suppression in participants with archived antiretroviral resistance including M184V/I.
PMID: 31430369
2019
The Journal of antimicrobial chemotherapy
Method: Primary INSTI resistance (-R) substitutions were T66I/A/K, E92Q/G, T97A, F121Y, Y143R/H/C, S147G, Q148H/K/R, N155H/S and R263K in IN.
Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir.
PMID: 30568974
2018
Open forum infectious diseases
Discussion: In these cases, genotypic analysis revealed that T97A emerged in addition to other mutations, including E92E/Q, E138E/K, and N155H.
HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy.
PMID: 29617822
2018
The Journal of infectious diseases
Abstract: INSTI-RAMs (S230R, R263K, N155H, and E92Q+N155H) were detected in 4 patients, no INSTI-RAMs were detected in 4 patients, and sequencing of the integrase gene was unsuccessful in 2 patients.
HIV mutation literature information.
PMID: 
2019
AIDS research and human retroviruses
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