Abstract: Among them, 7 polymorphisms (L74I, K103N, V106A, Y181C, G190A, T215I and P225H) were known to be drug resistance mutations, 7 polymorphisms (E6D, E35D, S37N, I93L, E169D, T200V and T200E were considered to be potential drug resistance mutations, and 6 polymorphisms (T39A, K43E, S68N, Q197K, T200V and E22
Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptase.
PMID: 21350368
2011
Journal of acquired immune deficiency syndromes (1999)
Result: Pre-therapy mutations associated with virologic failure, unadjusted for multiple comparisons, were E6D (p=0.023), K103R (p=0.046) and Q174K (p=0.015) in the polymerase domain and Q334H in the connection domain (p=0.045) [Table 2].
HIV mutation literature information.
PMID: 
2017
PloS one
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