Result: The time when half of the viral RTCs had completed reverse transcription was approximately 2 h later for HIV-1 with the E300R mutation (50% delay), 4 h later for HIV-1 with the E298R mutation (100% delay), and 30 min later for E297R (14% delay) than for WT HIV-1.
Result: This pattern was similar in TZM-bl cells, where the E298R and E300R mutant viruses replicated significantly less than the WT virus (P < 0.05) and E300R mutant HIV-1 had the least replication.
Result: Whi
Discussion: Optimal uncoating kinetics within 1 h of infection are tightly linked with HIV-1 infectivity, which may be why E300R mutant HIV-1 is less infective than E298R mutant HIV-1.
HIV mutation literature information.
PMID: 
2018
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