Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).
Abstract: Phenotypic analysis showed that E157Q results in minimal changes in RAL and DTG susceptibility.
Abstract: Six recombinant viruses were constructed containing integrase from clinical HIV-1 isolates found to harbour E157Q as the only integrase strand inhibitor (INSTI) resistance-related mutation.
Abstract: The HIV-1 integrase E157Q natural polymorphism has been reported to cause one case of raltegravir (RAL) and dolutegravir (DTG) failure.
Abstract: The previously reported case of E157Q-based resistance must have resulted from combined as yet unidentified integrase polymorphisms.
Abstract: Together with data retrieved from the Stanford
HIV Type 1 Integrase Natural Polymorphisms in Viral Variants Circulating in FSU Countries.
Abstract: The prevalence of minor/ accessory substitutions depended on HIV-1 variants, while the most notable findings were L74I in subtype A6 (93.1%) and E157Q in subtype B (44.0%).
HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters.
PMID: 28472323
2017
The Journal of antimicrobial chemotherapy
Result: By week 24, the dominant virus coexpressed T66I (99.5%), R263K (98.7%) and E157Q (94.1%) (Figure6a).
Result: Deep sequencing-based genotyping showed T66I selection occurred prior to R263K followed by E157Q, which may have compensated for the fitness compromise of R263K (Figure6a).
Result: Isolate 14997 acquired a mixture of different viruses with T66I, E92G, E157Q, H51Y and/or S147G representing 85.9%, 19.8%, 99.7%, 15.0% and 9.9% of variants at week 36 (Figure6c).
Result: The infrequent appearance of S230R,
Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States.
PMID: 28384058
2017
AIDS research and human retroviruses
Abstract: The most frequently detected mutation was E157Q.
The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration.
Discussion: An eventual de novo virological failure with resistance mutations may derive from preexisting rare polymorphisms, including E157Q and others.
Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome.
Result: Some secondary integrase mutations associated with resistance to EVG and/or RAL were detected as natural integrase polymorphisms, most often at very low frequencies (0.5-1%: V72T, L74M, A128T, and G163R) with few exceptions (19%: M50I; 59%: S119P/G/T/R; and 3.8%: E157Q).
Discussion: Of the INSTI RAMs detected as naturally occurring integrase polymorphisms, only L74M, T97A, E157Q, and G163R are considered secondary PMID: 28017912
2017
Infection, genetics and evolution
Abstract: Clusters of nucleoside reverse transcriptase mutations in subtype D and integrase E157Q variants in subtype B were observed.
Abstract: Polymorphisms associated with resistance against integrase inhibitor, mostly E157Q, were found in 21.5% sequences and associated with female (31.91% vs.
Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom.
Introduction: Recently, the French PRIMO cohort study detected isolated E157Q mutations in 1.5% of baseline samples 16.
Result: In isolation, these mutations are not reported to affect susceptibility to integrase inhibitors with the exception of E157Q, which confers low-level resistance to raltegravir and elvitegravir.
Result: Six individuals had minor or accessory mutations: one had L74M, two had V151I and three had E157Q.
HIV-1 Epidemiology, Genetic Diversity, and Primary Drug Resistance in the Tyumen Oblast, Russia.
HIV mutation literature information.
PMID: 
2017
HIV clinical trials
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