Result: The largest clusters with INSTI PDR transmission were cluster INSTI-1, with 5 nodes sharing the S230R mutation, formed by 4 cisgender men and 1 transgender woman, with median age 23 (20-32); and cluster INSTI-2, with 4 nodes, all men sharing the E157Q and G163K mutations and median age 28 (26-34).
Transmitted HIV drug resistance and subtype patterns among blood donors in Poland.
Abstract: Additionally, E157Q polymorphism was observed in 9.8% and
Result: E157Q polymorphism was the most prevalent (9.8%) resistance associated variant in the analysed dataset and was notably more common among female individuals (n = 4, 50.0%) compared to 8.4% (n = 14) among males, p = 0.004.
Result: In subtype B one cluster with NNRTI K101H/E138A mutation was observed, in four sequence pairs there was also evidence of the shared resistance patterns (NRTI: D67N/K291Q and T215V, NNRTI: V106I, integrase: E157Q).
Structural effects of HIV-1 subtype C integrase mutations on the activity of integrase strand transfer inhibitors in South African patients.
PMID: 34488561
2021
Journal of biomolecular structure & dynamics
Abstract: Only one INSTI-treated isolate (14.28%) harboured major mutations (G140A + Q148R) as well as the E157Q minor mutation.
Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations.
Abstract: CONCLUSIONS: Our analysis indicated that all RAM's that resulted in a change in the number of interactions with encompassing residues does not affect DTG binding, while accessory mutations E157Q and D232N could affect DTG binding leading to possible DTG resistance.
Abstract: Except for accessory mutant structure E157Q, only one MG contact was made with DTG, while DTG had no MG ion contacts and no DDE motif residue contacts for structure D232N.
Abstract: Of these,11.8% (34/287) of the sequences contained five different IN accessory mutations; namely Q95K, T97A, G149A, E157Q and D232N.
Discussion:
HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana.
Abstract: The most common major resistance mutation was E138AK (0.5%, 5/999), while the most common accessory resistance mutation was E157Q (1.8%, 18/999).
No difference in HIV-1 integrase inhibitor resistance between CSF and blood compartments.
PMID: 33693680
2021
The Journal of antimicrobial chemotherapy
Abstract: The HIV-1 integrase sequences from CSF presented resistance mutations for 9/27 (33.3%) and 8/32 (25.0%) for ARV-naive (L74I, n = 3; L74I/M, n = 1; T97A, n = 1; E157Q, n = 4) and ARV-treated (L74I, n = 6; L74M, n = 1; T97A, n = 1; N155H, n = 1) patients, respectively.
Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naive HIV Patients in Southeast China.
PMID: 33679129
2021
Drug design, development and therapy
Discussion: E157Q is a common polymorphic mutation selected by RAL treatment in HIV patients and by exposure to EVG in vitro.
Discussion: One major (E138K
Discussion: Similar to the study conducted by Liu et al, who first reported the presence of the E157Q mutation among Chinese ART-naive patients in 2019, the frequency of the integrase E157Q mutation was very low in China.
Discussion: The prevalence of the E157Q polymorphic mutation was 2.7% in INSTIs-naive patients from 17 French clinical centers, and 2.4% in ART-naive patients in Italy.
Discussion: These studies have demonstrated that the E157Q mutation itself has minimal effects on RAL and DTG activity and viral infectivity.
High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.
PMID: 32105319
2020
The Journal of antimicrobial chemotherapy
Result: The most common integrase polymorphism was E157Q, which was detected in 12 participants (6 of these also had L74I).
HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon.
PMID: 31830799
2020
AIDS research and human retroviruses
Abstract: Accessory RAMs were present in 8.1% (n = 3/37) of the sequences, of which one sequence contained solely E157Q, and another Q95K.
Abstract: One patient sequence had three accessory RAMs (G140E, E157Q, and G163R).
HIV mutation literature information.
PMID: 
2021
Pathogens (Basel, Switzerland)
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