Result: E138X variants exhibited no significant differences in replicative kinetics with respect to wild-type HIV-1 in a 10-day monoculture assay.
Result: In the remaining 13 countries, E138X frequencies ranged from 5.6 to 21% in B*18-expressing persons compared with only 0.37-10% in non-B*18-expressing persons.
Result: Moreover, the enrichment of reverse transcriptase-E138
Result: To assess the replicative cost of reverse transcriptase-E138X (as a surrogate of its potential to persist upon transmission) we constructed recombinant HIV-1 variants harbouring E138A, E138G, and E138K and assessed their in-vitro replicative competence compared with wild-type HIV-1 (E138).
HIV mutation literature information.
PMID: 
2017
AIDS (London, England)
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