literature

HIV mutation literature information.

Molecular characterisation of the pol gene of vertically transmitted HIV-1 strains in children with virological failure.

PMID: 35302390 2022 AIDS research and human retroviruses

Abstract: At BL, K103N (5), E138A/G (4) and M184V (3) were the most common mutations.

Single Oral Doses of MK-8507, a Novel Non-Nucleoside Reverse Transcriptase Inhibitor, Suppress HIV-1 RNA for a Week.

PMID: 34654041 2022 Journal of acquired immune deficiency syndromes (1999)

Result: The E138G and V179D variants were detected in 1 participant each in the 600 mg panel before dosing, but were not detected postdose.

Table: E138G

Discussion: Two NNRTI-resistance-associated variants (E138G and V179D) were detected in 1 participant each in the 600 mg panel before dosing, but were not detected postdose, indicating that MK-8507 did not select for these.

Phase 2 Open-Label Study of Long-Term Safety, Tolerability, and Antiviral Activity of Rilpivirine in Antiretroviral-Naive Adolescents Living with HIV-1.

PMID: 34871089 2022 Antimicrobial agents and chemotherapy

Method: Patients with previously documented HIV-2 infection, with active AIDS, and with documented genotypic evidence of >=1 NNRTI resistance-associated mutation (RAM) from a predefined list of the following NNRTI RAMs at screening were excluded: A98G, L100I, K101E, K101P, K101Q, K103H, K103N, K103S, K103T, V106A, V106M, V108I, E138A, E138G,

Brief Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide Efficacy in Participants With Preexisting Primary Integrase Inhibitor Resistance Through 48 Weeks of Phase 3 Clinical Trials.

PMID: 34897227 2022 Journal of acquired immune deficiency syndromes (1999)

Table: E138A/G

Switching efavirenz to rilpivirine in virologically suppressed adolescents with HIV: a multi-centre 48-week efficacy and safety study in Thailand.

PMID: 35001501 2022 Journal of the International AIDS Society

Method: We excluded individuals with prior evidence of NNRTI-associated resistance mutations based on the IAS-USA HIV drug-resistance mutations list (2019) (V90I, A98G, L100I, K101E/H/P/Q/R/N, K103N/S, V106A/M/I, V108I, E138K/A/G/Q/R, V179D/F/L/T, Y181C/I/V, Y188L/C/H, G190A/S/E,H221Y, P225H, F227L/C/R,

Could Long-Acting Cabotegravir-Rilpivirine Be the Future for All People Living with HIV? Response Based on Genotype Resistance Test from a Multicenter Italian Cohort.

PMID: 35207677 2022 Journal of personalized medicine

Method: Furthermore, we excluded people with the following mutations for NNRTI: L100I, K101E/H/NP/Q, E138A/G/K/Q/R, V179L, Y181C/F/G/I/S/V, Y188L, G190A/C/E/Q/S/T/V, H221Y, F227C/L, and M230L.

Prevalence of HIV-1 drug resistance in Eastern European and Central Asian countries.

PMID: 35061671 2022 PloS one

Result: The most frequent NNRTI DRM in Russia (32/465; 6.9%), Azerbaijan (7/96; 7.3%), and Uzbekistan (7/178; 3.9%) was E138A; this mutation was also found in Armenia (5/120; 4.2%) and Belarus (9/158; 5.7%); in Tajikistan, another substitution, i.e., E138G was found (1/54; 1.9%).

Discussion: The predominant NNRTI DRMs included E138A/G, which is the natural polymorphic mutation for sub-subtype A6, was previously shown to have a prevalence of 7% frequency in Russian HIV-infected patients, and is associated with low-level DR to rilpivirine, which is not taken into account in the assessment of PDR; V106I, which alone causes a minimal reduction in NNRTI susceptibility; and

PMID: 35300056 2022 Pharmacogenomics and personalized medicine

Result: NGS was more sensitive in detecting low-frequency mutations and a total of 4 mutations were detected by NGS but missed by Sanger sequencing which including M184V (1.31%), K65E (3.72%), E138G (1.21%), and Y188C (1.04%).

Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China.

PMID: 34567064 2021 Frontiers in genetics

Result: In particular, two TCs contained shared DRMs of E138G + V179E and V106I + V179D in Baise and Qinzhou cities, respectively.

HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China.

PMID: 33668946 2021 Pathogens (Basel, Switzerland)

Result: At baseline, mutations with a frequency of 20% and above were NRTI-related, such as M184VI (2.0%, 1/49), and NNRTI-related like K103N (14.3%, 7/49), E138AG (4.1%, 2/49), V179D (2.0%, 1/49) and P225H (2.0%, 1/49).

Result: The most common drug resistance mu

Discussion: Compared with the baseline, the HIVDR mutations, such as N88D, K65R, M184VI, K103N, E138AG, V179D and P225H, still existed but the frequency gradually decreased, consistent with earlier studies.

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