The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014-2017.
Abstract: 48 DRMs were identified from 43 samples, indicating a drug resistance prevalence of 12.1% (43/356), which include seven protease inhibitors (PIs) accessory DRMs (Q58E, L23I and
Result: We analyzed the following specific DRMs: 1) 66.7% (32/48) DRMs were on nonnucleoside reverse transcriptase inhibitors (NNRTIs) as: V179E (n = 12), E138A (n = 4), Y188D (n = 1), K103N (n = 2), A98G (n = 1), K238N (n = 2), V179D (n = 8), E138G (n = 1), G190E (n = 1).
Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.
Prevalence of HIV-1 Integrase Strand Transfer Inhibitor Resistance in Treatment-Naive Voluntary Counselling and Testing Clients by Population Sequencing and Illumina Next-Generation Sequencing in Taiwan.
Abstract: The most common INSTI resistance-associated mutations were G163K (0.4%) and E138A (0.4%).
Result: The most common INSTI RAMs were G163K (0.4%) and E138A (0.4%) (Figure 3).
Table: E138A
Figure: Overall, 0.4% of the patients had drug resistance-associated mutations to G163K and E138A.
Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.
PMID: 33654530
2020
The Pan African medical journal
Table: E138A
Genotyping and antiretroviral drug resistance of human immunodeficiency Virus-1 in Jazan, Saudi Arabia.
Abstract: Mutations associated with antiretroviral drugs include (V82A+ Result: Resistance mutations to NNRTI were detected in 3/57 (5.3%), these mutations were V179VD, V106I, and E138A.
Result: The patient with V106I mutation was genotype CRF01-AE, and had resistance to the antiretroviral drugs, ETR, NVP, and RPV, the patient with E138A mutation, was genotype B and had resistance to two antiretroviral drugs: ETR, and RPV.
Result: Three patients had resistance mutations to NNRTI (V179VD, V106I, and E138A).
Table: E138A
Resistance to HIV integrase strand transfer inhibitors in Argentina: first interim survey.
PMID: 31037930
2019
Revista espanola de quimioterapia
Table: E138A/E
Table: E138A
High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO.
PMID: 30891603
2019
The Journal of antimicrobial chemotherapy
Discussion: Furthermore, previous studies evaluating the variability of the IN gene revealed that amino acid variations at codon 138 (E138A/D/K/T) could arise from G-to-A hypermutation resulting from APOBEC-mediated RNA editing, and also from natural polymorphism during viral replication.
[Prevalence of antiretroviral drug resistance in treatment-naive injecting drug users infected with HIV-1 in Guangzhou, 2008-2015].
PMID: 30744272
2019
Zhonghua liu xing bing xue za zhi
Abstract: The highest mutation rate of E138A was detected in subtype CRF08_BC (3.23%).
Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.
Abstract: The longest mean survival times were calculated for the Result: Mutations E138A/G/K/R were found in 99 of 186 viruses (52.9%) showing RPV resistance, which account for 40% of all NNRTI-resistant viruses.
Result: The NNRTI mutations at position E138 (E138A/G/K) had the longest mean Kaplan-Meier estimates (8.0 years, 95% CI 5.8-10.2 / 7.9 years, 95% CI 5.4-10.3 / 6.7 years, 95% CI 6.7-6.7) compared to all other TDRMs observed in this study cohort.
Result: The most common TDRMs found in baseline samples were the T215 revertants, followed by E138A/G/K/Q/R, K103NS, V179DE and M41L (S1 Table).
High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014.
PMID: 30640198
2019
The Pediatric infectious disease journal
Result: Twenty-nine (9.5%) of the children had additional NNRTI mutations (A98G, E138A/G/K/Q, H221Y, and M230L) that confer resistance to second generation NNRTI drugs etravirine and rilpivirine.
HIV mutation literature information.
PMID: 
2020
PloS one
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