Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.
PMID: 31617907
2020
The Journal of antimicrobial chemotherapy
Abstract: Among the 29 relatively common INSTI-selected mutations, 24 emerged as candidates for inclusion on a list of INSTI surveillance drug-resistance mutations: T66A/I/K, E92G/Q, G118R, F121Y, E138A/K/T, G140A/C/S, Y143C/H/R/S, S147G, Q148H/R/K, N155H, S230R and R263K.
[Prevalence of transmitted drug resistance in HIV-infected treatment-naive patients in Chile].
Abstract: The mutations in reverse transcriptase were M41L, L210W, D67N, K70E, M184V, K103N (6.36%, 95% CI 3.5-10.4), G190A, E138A, K101E, and I84V in protease.
Occurrence of the S230R integrase strand inhibitor mutation in a treatment-naive individual case report.
Result: In four (4) of the patients carrying resistance associated mutations in the urban setting, 6 resistance mutations to NRTIs: [M41L (2), E44D (1), K65R (1), Discussion: K238T, V179E, M230L and E138A found in the participants in the urban setting conferred resistance to NNRTIs.
Discussion: The mutation E138A found both in rural and urban setting confers low-level resistance to second generation NNRTIs and their presence alone or in conjunction with the mutation M138I causes decreased susceptibility of the virus to ETV and RPV.
Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana.
Abstract: CONCLUSION: This study found major drug resistance mutations, E138A and K65R in the RT gene that confer high level resistance to most NNRTIs and NRTI respectively.
Abstract: Nucleotide sequencing of amplified samples revealed the presence of major drug resistance mutations in two (2) samples; E138A in one sample and another with K65R.
Result: No major PR-related DRM was observed in the samples whilst major RT-related DRMs in two (2) samples were found; E138A in one sample and another with K65R.
Discussion: In a similar study, E138A was found
Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia.
Result: Overall, the 10 most common mutations were M184V (81%), K103N (65.5%), Y188C (36.2%), Y181C (36.2%), V106A (36.2), K65R (34.5%), K70RTQNE (32.8%), G190ASV (31.0%), K101EHP (31.0%) and E138AGQ (29.3%).
Result: The ten most common mutations to the drug class NNRTI included K103N (65.5%), V106A (36.2%), Y188C/L (36.2%), Y181C/V(36.2%), G190ASV(31%),
Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda.
PMID: 32853364
2020
The Journal of antimicrobial chemotherapy
Abstract: Two patients, one with E138A/G140A/Q148R/G163R and one with E138K/G140A/S147G/Q148K, displayed the highest reported resistance to raltegravir, elvitegravir and even dolutegravir.
In vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral-therapy-naive HIV-infected men who have sex with men.
Abstract: Three of the 10 subjects exhibited the presence of major (abundance, >= 20%) viral populations carrying DRM at early/acute stage that later, at the chronic stage, dropped drastically (V106M) or remained highly abundant (E138A).
Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia.
Abstract: The most frequently observed NNRTIs-associated mutations common to both algorithms were K103N (2%), Y188L (2%), K101E (2%), and V106A (2%), while E138A (2%) was observed according to IAS-USA only.
Result: On the contrary, E138A mutation, which is associated with reduced RPV and ETR susceptibility, was detected by the IAS-USA mutation list only in two individuals (3.92%) (Table 2).
Table: E138A
Discus
Discussion: E138A mutation, which is associated with a decreased response to ETR and RPV according to the IAS-USA mutation list, was found in 3.9% (2/51) of the specimens showing a similar frequency of detection in previous reports from Ethiopia.
Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.
HIV mutation literature information.
PMID: 
2020
The Journal of antimicrobial chemotherapy
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