"Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5""-(4""-amino-1"",2""-oxath iole-2"",2""-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients."
PMID: 10875608
2000
AIDS research and human retroviruses
Abstract: E138K, not E138A, is a known TSAO-specific resistance mutation, emerging under selective pressure in vitro.
Abstract: As TSAO derivatives have not been used in the clinical setting, the presence of the E138A mutation at a frequency of 6.7% in our study of 90 TSAO-inexperienced HIV-seropositive individuals implies that 138A of the RT must be a natural variant and that the mutant virus is replication competent.
Abstract: HIV-1 samples from six patients undergoing diverse anti-HIV therapies possessed the E138A mutation in their reverse transcriptase (RT) genome.
Abstract: In addition, we have demonstrated through phenotypic analysis of the E138A and A98S
HIV mutation literature information.
PMID: 
2000
AIDS research and human retroviruses
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