Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/AIDS in a Minority Area, China.
Abstract: The prevalence of TDR for non-nucleoside reverse transcriptase inhibitors (NNRTIs) is higher than that of other inhibitors, with a relatively high prevalence of three mutations [V179D/E/DE
Result: Besides, 37.38% (40/107) of individuals carrying TDR were involved in the network, and K103N (42.5%, 17/40) was the most frequent TDR-associated mutation, followed by E138A (15%, 6/40), I54M (7.5%, 3/40), and Q58E (7.5%, 3/40).
Result: The most frequent NNRTI-associated mutation in our study was V179D/E/DE (4.93%), followed by K103N/KN (3.11%) and E138A/G (1.52%).
HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.
PMID: 34762770
2021
Journal of the International AIDS Society
Result: 5.2% PLB; p = 1.00) in ASPIRE (Table 1) but E138A was detected more frequently in DVR seroconversions in the Ring Study.
Result: E138A was the most frequently detected mutation in HIV-positive ASPIRE participants.
Result: All E138A-containing bulk-cloned viruses were tested for cross-resistance to commonly used NNRTIs for ART, including nevirapine, efavirenz, rilpivirine and etravirine.
Result: Due to concerns that E138A could reduce the protective efficacy of DVR, we phenotyped clonal recombinant isolates from two samples from each arm (DPV-1, DPV-2, PLB-1 and PLB-2) to further investigate DPV susceptibility.
Result: Major NNRTI mutations detected included K101E, K103N, <
Genetic Diversity and Acquired Drug Resistance Mutations Detected by Deep Sequencing in Virologic Failures among Antiretroviral Treatment Experienced Human Immunodeficiency Virus-1 Patients in a Pastoralist Region of Ethiopia.
Result: The largest PDR-related cluster within network contained DRM propagation of E138A, V82VF, V179D, V179VD, and V106I, while the remaining two PDR-related clusters are only involved in V106I propagation.
High-level resistance to bictegravir and cabotegravir in subtype A- and D-infected HIV-1 patients failing raltegravir with multiple resistance mutations.
PMID: 34453542
2021
The Journal of antimicrobial chemotherapy
Abstract: However, combinations of primary INSTI-resistance mutations such as E138A/G140A/G163R/Q148R or E138K/G140A/S147G/Q148K led to decreased susceptibility to both cabotegravir (fold change in EC50 values from 429 to 1000x) and bictegravir (60 to 100x), exhibiting a high degree of cross-resistance.
Dolutegravir in the long term in children and adolescents: frequent virological failure but rare acquired genotypic resistance.
Abstract: Resistance to dolutegravir (mutations G118R and E138A in the integrase gene) emerged in one adolescent (0.7% of subjects, 2.3% of those with VF).
HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.
Molecular Network Analysis Reveals Transmission of HIV-1 Drug-Resistant Strains Among Newly Diagnosed HIV-1 Infections in a Moderately HIV Endemic City in China.
Result: In the CRF01_AE network, there were five clusters with TDR mutations including two with M46L (PI mutations, n = 6) and one each with A98G (NNRTI mutations, n = 4), E138A (NNRTI mutations, n = 3), and K103R/V179D (NNRTI mutations, n = 3).
Result: Transmitted drug resistance mutations detected in more than 10 cases included PI [Q58E (n = 51) and M46ILV (n = 46)] and NNRTI [K103N (n = 26), E138AGKQ (n = 25),
Phylogenetic and Drug-Resistance Analysis of HIV-1 Sequences From an Extensive Paediatric HIV-1 Outbreak in Larkana, Pakistan.
Abstract: Of the treatment-naive participants, the two most common mutations were RT: E138A (8%) and RT: K219Q (8%).
Result: Amon
Result: Among ART naive individuals, 15 (30%) had drug resistance mutations (DRM); the most common of which were the Reverse Transcriptase (RT):E138A (8.0%) and RT:K219Q (8.0%) mutations.
Table: E138A
Discussion: The most prevalence DRM identified among both ART-experienced and ART-naive individuals was RT:E138A which confers a high-level resistance to NNRTIs such as Rilpivirine.
HIV mutation literature information.
PMID: 
2021
Frontiers in public health
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