Identification and characterization of a temperature-sensitive mutant of human immunodeficiency virus type 1 by alanine scanning mutagenesis of the integrase gene.
Abstract: However, during infection at the nonpermissive temperature of 39.5 degrees C, K136A/E138A is capable of only one round of integration.
Abstract: In the ts mutant virus, the lysine at amino acid 136 and the glutamic acid at amino acid 138 of integrase have been replaced with alanines (K136A/E138A).
Abstract: It is the temperature at which the K136A/E138A virion is synthesized, not the temperature at which infection occurs, which determines the ability of the virus to integrate.
Abstract: We demonstrate that the defect responsible for the ts phenotype of K136A/E138A is localized to a step after proviral formation and integr
HIV mutation literature information.
PMID: 
1995
Journal of virology
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