Abstract: We determined five crystal structures: wild-type reverse transcriptase-double-stranded DNA (RT-dsDNA)-AZTppppA; AZT-resistant (AZTr; M41L D67N K70R T215Y K219Q) RT-dsDNA-AZTppppA; AZTr RT-dsDNA terminated with AZT at dNTP- and primer-binding sites; and AZTr apo reverse transcriptase.
Introduction: The mutations commonly associated with excision-mediated AZT resistance are M41L, D67N, K70R, L210W, T215Y, PMID: 21390473
2010
Acta dermatovenerologica Alpina, Pannonica, et Adriatica
Abstract: Ninety percent of sequences with genotypic resistance harbored M184V, M41L, K103N, D67N, and/or T215Y.
Prevalence of drug resistance and associated mutations in a population of Hiv-1+ Puerto Ricans in 2005.
PMID: 23875516
2010
Boletin de la Asociacion Medica de Puerto Rico
Abstract: The reverse transcriptase mutations with the highest frequency of expression were M184V, K103N and D67N.
Result: Analysis of RT mutations for 2005 demonstrated that the highest degree of expression was for M184V (41.3%), K103N (25.3%), and D67N (20.5%).
Nucleoside and nucleotide analogs select in culture for different patterns of drug resistance in human immunodeficiency virus types 1 and 2.
PMID: 19064892
2009
Antimicrobial agents and chemotherapy
Abstract: In HIV-1 subtype B, TFV-3TC and ZDV-3TC selected for M184I and D67N, respectively.
Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy.
Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa.
Abstract: HIV-1-associated thymidine analogue mutations (M41L, D67N, K70R, L210W, and T215Y/F) were not observed, with the exception of K70R, which was present together with K65R and Q151M in a strain from 1 patient.
Result: HIV-1-associated thymidine analogue mutations (M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E) were not found, with the exception of K70R, which was present in a strain from 1 patient (in conjunction with K65R
Emergence of primary NNRTI resistance mutations without antiretroviral selective pressure in a HAART-treated child.
The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapy.
Method: NRTI mutations included K65R and K70E (associated with TDF resistance), thymidine analog mutations (TAMs) M41L, D67N, K70R, L210W, T215Y, T215F, K219Q, and K219E, and multinucleoside mutations, including the 69 insertion complex and the 151 complex.
Result: The most frequent TAMs were T215 F/Y (73%), D67N (53%), K70R (36%), M41L (36%), K219 Q/E (23%), and L210W (23%).
Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naive patients.
Introduction: The excision mechanism is associated with mutations at the polymerase domain, including M41L, D67N, K70R, L210W, T215F/Y and K219E/Q (excision-containing mutations, EEMs, also known as thymidine analogue-associated mutations [TAMs]).
Result: Among these isolates, 6 contained the known RTI-associated resistant mutations, D67N (n=2), K238S (n=2) (http://www.hiv.lanl.gov/content/index), V108I/K238S (n=1) and V106A/V108I/K238S (n=1), and thus were
Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: evidence for low level of transmitted drug resistance.
PMID: 19433560
2009
Antimicrobial agents and chemotherapy
Abstract: Two (1.6%) unrelated patients harbored nucleoside reverse transcriptase inhibitor- and nonnucleoside reverse transcriptase inhibitor-resistant viruses (mutations: M41L, D67N, M184V, L210W, T215Y or T215F, and K103N).
HIV mutation literature information.
PMID: 
2010
Nature structural & molecular biology
Browser Board
Co-occurred Entities
Filtrator
ViMRT