literature

HIV mutation literature information.

Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.

PMID: 29026792 2017 Iranian journal of public health

Table: D67N

Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.

PMID: 29049402 2017 PloS one

Result: Among the two TAMs pathways, TAM-2 which features D67N, K70R, T215F, and K219E/Q mutations was more common than the TAM-1 which features M41L, L210W and T215Y.

Table: D67N

Discussion: Lastly, the study in one side identified an increasing common mutational pathways overtime with two thymidine non-analog (M184V and K65R) and three thymidine analog (D67N, K70R and K219E) major nucleoside reverse transcriptase inhibitor (NRTI)-associated DRMs and fo

Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.

PMID: 29074854 2017 Scientific reports

Abstract: Overall, 7.3% transmitted and 34.3% acquired DRMs were found, including M184V, thymidine analogue mutations (T215F, D67N, K70R, K219Q), NNRTIs (L100I, Y181C, K103N, V108I, Y188L), and PIs (V82L).

Table: D67N

Discussion: In addition to the resistance mutations to NRTIs (M184V and the TAM T215F) and NNRTIs (L10

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.

PMID: 29117130 2017 Viruses

Result: The most frequently observed reverse transcriptase (RT) drug resistance mutations in NRTI-experienced patients were M184I/V (64.2%), D67N (25.9%), K70R (19.6%), K219Q/E (17.9%) and T215Y/F (13.4%).

HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study.

PMID: 29244809 2017 PloS one

Table: D67N

HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China.

PMID: 28750025 2017 PloS one

Table: D67N

The Genotyping Resistance Profile of the Pol Gene Detected in Blood of Newly Diagnosed HIV-Positive Men Is Durably Archived in the Gut Whatever the Time of Initiation of cART.

PMID: 28402970 2016 Intervirology

Abstract: Those mostly detected were related to the resistance to nucleos(t)ide (D67N, L210W, T215A, T69D) and nonnucleoside (K103N, V106I, V179I) inhibitors.

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.

PMID: 27645238 2016 Antimicrobial agents and chemotherapy

Method: The virus 6TAMs, containing six resistance mutations in HIV-1 RT (M41L, D67N, K70R, L210W, T215Y, and K219Q) that confer resistance to thymidine analogs, was constructed by cloning a PCR-amplified RT-encoding fragment from HIV-infected patient-derived plasma.

Surveillance of HIV Transmitted Drug Resistance in Latin America and the Caribbean: A Systematic Review and Meta-Analysis.

PMID: 27355626 2016 PloS one

Result: For this region, the most prevalent TDR mutations for the whole study period were K103N (2.0%), M184V (0.9%), M41L (0.8%), and D67N (0.6%).

Result: This decreasing trend was associated with reductions in frequency of several DR mutations including D67N, K70R, M184V, L210W,

Discussion: 3.1%, p<0.0001), with a significant reduction in the frequency of M184V and of most thymidine analogue mutations (TAM), including D67N, K70R, L210W, T215F, T215Y, and K219E.

HIV Drug Resistance in Antiretroviral-Naive Patients in Mexico After 10 Years: Is There a Difference?

PMID: 27353350 2016 AIDS research and human retroviruses

Abstract: In both groups, mutations in N88D protease inhibitor were identified, D67N and T69D were found for nucleoside reverse transcriptase inhibitors (NRTIs), and K103N was found for non-nucleoside reverse transcriptase inhibitors.

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