literature

HIV mutation literature information.

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Method: Thymidine-analog mutations were defined as the NRTI-SDRMs M41L, D67N/G/E, K70R, L210W, T215Y/F/S/C/D/E/I/V, and K219Q/E/N/R.

High HIV-1 Virological Failure and Drug Resistance among Adult Patients Receiving First-Line ART for At least 12 Months at a Decentralized Urban HIV Clinic Setting in Senegal before the Test-and-Treat.

PMID: 34025122 2021 Infectious diseases

Table: D67N

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana.

PMID: 33807382 2021 Viruses

Introduction: INSTI-naive highly treatment-experienced patients failing DTG cART have been found to have a virus with DRMs including G118R, D67N; H51H/Y, G118R, E138E/K, and less commonly R263R/K, V260I, R263R, N155H, G118R, and E138E.

Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.

PMID: 33014372 2020 SAGE open medicine

Table: D67N

[Prevalence of transmitted drug resistance in HIV-infected treatment-naive patients in Chile].

PMID: 33844760 2020 Revista medica de Chile

Abstract: The mutations in reverse transcriptase were M41L, L210W, D67N, K70E, M184V, K103N (6.36%, 95% CI 3.5-10.4), G190A, E138A, K101E, and I84V in protease.

Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.

PMID: 33654530 2020 The Pan African medical journal

Result: Predominant NNRTIs mutations were K103N, Y181C, G190A, H221Y, and K101E; NRTIs were M184V, Y115F, K65R, K70R, D67N and PIs were I54V, F53L and V82A (Table 2).

Table: D67N

Discussion: Our findings reveal major mutations conferring resistance to NRTIs with M184V, Y115F,

The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014-2017.

PMID: 33347449 2020 PloS one

Abstract: 48 DRMs were identified from 43 samples, indicating a drug resistance prevalence of 12.1% (43/356), which include seven protease inhibitors (PIs) accessory DRMs (Q58E, L23I and I84M), two PIs major DRMs (M46I, M46L), seven nucleoside RT inhibitors DRMs (D67N, K70Q

Result: 2) Seven nucleotide reverse transcriptase inhibitors (NRTIs) were: D67N (n = 4), M184L (n = 1), K70Q (n = 1), K219R (n = 1).

Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern Tanzania.

PMID: 32986709 2020 PloS one

Result: M184V mutation was associated with high-level resistance to emtricitabine, and lamivudine; while K70R and D67N are among thymidine analogue-associated resistance mutations (TAM) reducing the susceptibility of all current NRTI in use.

Result: Identified TAMs were T215YF (n = 9), K219QE (n = 7), K70R (n = 7), D67N (n = 6), M41L (n = 4), and L210W (n = 3) (Table 3).

Result: The most frequent NRTI resistance-associated mutations were M184V (68%), K70R (28%), and D67N (24%) (Fig 4

Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia.

PMID: 32804970 2020 PloS one

Abstract: Common TAMs were K70RTQNE (32.8%), K219QE (22.4%), D67N (17.2%) and T215IT (15.5%).

Discussion: In terms of HIVDR to NRTI, the prevalence of any TAMs was at 32.8% and the most common TAM's were K70R/T/Q/N/E (32.8%), K219Q/E (22.4%), D67N (17.2%), T215IT (15.5%) and M41L (5.2%).

Discussion: The high prevalence of individual TAMs (D67N and K70R) or TAMs in combination (M41L with T215Y) reduces susceptibility to Zidovudine (a ke

Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase.

PMID: 32747359 2020 Antimicrobial agents and chemotherapy

Abstract: Clinically relevant combinations of TAMs, such as M41L/T215Y or D67N/K70R/T215F/K219Q, enhance the ATP-mediated excision of AZT monophosphate (AZTMP) from the 3' end of the primer, allowing DNA synthesis to continue.

Abstract: In HIV-1, development of resistance to AZT (3'-azido-3'-deoxythymidine) is mediated by the acquisition of thymidine analogue resistance mutations (TAMs) (i.e., M41L, D67N, K70R, L210W, T215F/Y, and K219E/Q) in the viral reverse transcriptase (RT).

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