In vitro selection of HIV-1 CRF08_BC variants resistant to reverse transcriptase inhibitors.
PMID: 25482475
2015
AIDS research and human retroviruses
Abstract: As expected, M184I alone, or with V90I or D67N, decreased 3TC susceptibility by over 1,000-fold.
Abstract: Initial mutations, in combination with other previously reported substitutions (K20R, D67N, V90I, K101R/E, V106I/A, V108I, F116L, E138R, A139V, V189I, G190A, D218E, E203K, H221Y, F227L, N348I, and
HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.
PMID: 25141905
2014
Journal of the International AIDS Society
Introduction: There are two TAM pathways: type I (M41L, L210W and T215Y) and type II (D67N, K70R, T215F and K219Q/E); the former conferring higher levels of resistance and cross-resistance.
Result: A total of 35 patients had at least 1 TAM, with the following distribution: M41L (16%), D67N (15%), K70R (9%), L210W (11%), T215Y (16%), T215F (11%), K219Q (5%) and K219E (2%).
The case for addressing primary resistance mutations to non-nucleoside reverse transcriptase inhibitors to treat children born from mothers living with HIV in sub-Saharan Africa.
PMID: 24439027
2014
Journal of the International AIDS Society
Abstract: The D67N thymidine-analogue mutation was observed in only two children whose mothers had received chemoprophylaxis of mother-to-child transmission (MTCT).
Result: In addition, the D67N thymidine-analogue mutation (TAM) was observed in only two children whose mother had received prevention of HIV MTCT.
Table: D67N
HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study.
Method: In this study, HIV-2 resistance mutations were identified using the list generated by the 'Collaborative HIV and Anti-HIV Drug Resistance Network', leading to the following mutations in reverse transcriptase - K65R, D67G/N, N69S/T, K70N/R, L74V, Result: The most prevalent resistance mutations to NRTI were the following: M184V (n = 17, 81%), Q151M (n = 5, 24%), S215F/Y (n = 5, 24%), V111I (n = 4, 19%), K65R (n = 3, 14%), M184I (n = 2, 10%), and D67N (n = 2, 10%).
Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.
Result: D67N accounted for 2.8% and caused AZT and d4T resistance.
Result: HNHIV46, HNHIV74, HNHIV77, and HNHIV137 were clustered together, with HNHIV46 and HNHIV137 having A71V, D67N, K101E, and G190A mutations, HNHIV74 having A71T mutation, and HNHIV77 having A71V and K103N mutations.
Result: HNHIV97 locus mutations included D67N, T69A, K70R, T215Y, K219E, K103N, and Y181C.
Discussion: Results from the HIV-1 drug resistance mutation research by the Inter
Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.
Abstract: Thymidine analogue resistance mutations (TAMs) in HIV-1 reverse transcriptase (RT) associate in two clusters: (i) TAM1 (M41L, L210W and T215Y) and TAM2 (D67N, K70R, K219E/Q, and sometimes T215F).
Limited evolution but increasing trends of primary non-nucleoside reverse transcriptase inhibitor resistance mutations in therapy-naive HIV-1-infected individuals in India.
Abstract: HIV-1 resistance to zidovudine [AZT (azidothymidine)] is associated with selection of the mutations M41L, D67N, K70R, L210W, T215F/Y and K219Q/E in RT (reverse transcriptase).
Introduction: HIV-1 resistance to AZT is associated with selection of the thymidine analog mutations (TAMs) M41L, D67N, K70R, L210W, T215F/Y and K219Q/E in RT.
Result: Consistent with previously published data, we found that RTs
HIV-1 pol diversity among female bar and hotel workers in Northern Tanzania.
HIV mutation literature information.
PMID: 
2015
AIDS research and human retroviruses
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