Prediction of drug-resistance using genotypic and docking analysis among anti-retroviral therapy naive and first-line treatment failures in Salem, Tamil Nadu, India.
Discussion: In contrast to these earlier reports that identified a limited number of NRTI mutations (T215D, K219Q and D67G, V75A) with a low overall frequency (4.2% and 5.1%, respectively) in newly infected Iranian cases, we detected a variety of NRTI SDRMs (M41L, D67N, K70R, V75M, F116Y, M184V, L210W, T215Y, and K219E) with a higher overall frequency (10%) in chronically infected IDUs in the city of Sanandaj (Table 2).
Genetic Characteristics of CRF01_AE Among Newly Diagnosed HIV-1-Infected 16- to 25-Year Olds in 3 Geographic Regions of Guangxi, China.
Result: Two TDR mutations, M46I (2) and I50V (1) were found in the protease region, and the other eight TDR mutations, K65E(1), D67N(1), T69N(1), K103N(1), Y181C(2), G190E(1), L210W(1), and P225H(1) were from the reverse transcriptase fragment.
Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.
Discussion: Despite the extensive use of thymidine analogues like AZT or D4T in Ethiopia and unlike previous similar studies, TAMs characterized by the mutations M41L, L210W, T215Y (TAM-path 1) and D67N, K70R, T215F, K219Q/E (TAM-path 2) were lacking in the current study indicating a recent period of virological failure.
The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.
Result: Taking into account multiple mutations together, the thymidine analog mutations (TAM) pathway 1 (including M41L, L210W, and T215Y) was selected in 40.8% of the patients, whereas TAM-2 (including D67N, K70R, T215F, and 58 K219Q/E) was present in 42.2%.
Result: The M41L, D67N, V118I, L210W,
Discussion: Resistance to NRTIs in multifailed patients was related to the presence of the TAMs M41L, D67N, L210W, and K219Q.
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
Discussion: Indeed, other NRTI DR mutations as M41L, D67N, K70R, L210W, and T215Y/F.
Discussion: We observed a significant decrease in the frequency of NRTI PDR mutations (D67N, K70R, M184V, T215Y) and an increase in the frequency of K103N (Fig 4), consistent with a long-term decrease in NRTI PDR and increase in NNRTI PDR in Honduras since the beginning of the national ART programme.
Outcome of patients on second line antiretroviral therapy under programmatic condition in India.
Characterization of two HIV-1 infectors during initial antiretroviral treatment, and the emergence of phenotypic resistance in reverse transcriptase-associated mutation patterns.
Discussion: This report indicated that K70R was followed by T215Y and accumulated the cluster mutation M41L/D67N/K70R/T215Y (K219Q), but herein we observed no cluster.
HIV mutation literature information.
PMID: 
2015
Current HIV research
Browser Board
Co-occurred Entities
Filtrator
ViMRT