Method: In total, 94 of 100 samples from patients failing ARV treatment also carried HIV-1 NRTI resistane mutations including M184V (82%), K65R (35%), L74I (19%), M41L (17%) or D67N (17%).
Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway.
PMID: 29275329
2018
The Journal of biological chemistry
Abstract: Here, we demonstrate that mutant M41L/D67N/K70R/S215Y HIV-2 RT lacks ATP-dependent excision activity, and recombinant virus containing this RT remains susceptible to AZT inhibition.
Abstract: Interestingly, recombinant HIV-2 carrying a mutant D67N/K70R/M73K RT showed 10-fold decreased AZT susceptibility and increased rescue efficiency on AZT- or tenofovir-terminated primers, as compared with the double-mutant D67N/K70R.
Abstract: Mutations of the excision pathway such as M41L, D67N,
Distinct Pattern of Thymidine Analogue Mutations with K65R in Patients Failing Tenofovir-Based Antiretroviral Therapy.
PMID: 29084434
2018
AIDS research and human retroviruses
Introduction: Based on significant previous research of DRMs, TAMs have been described to associate into one of two distinct pathways: TAM-1 (M41L, L210W, T215Y) or TAM-2 (D67N, K70R, T215F, K219E/Q).
Introduction: For all TAMs, with the exception of K219E, D67N, and K70R, there was no acquisition from S1 to S2 in patients on TDF, whereas the mean acquisition rates of individual TAMs in the patients on AZT varied from 0.005 mutations per month to 0.019 mutations per month.
Introduction: However, three males in the study exhibited the K65R, K219E +- PMID: 28627486
2018
Antiviral therapy
Abstract: Among individuals with at least one DRM, we found evidence that any nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) resistance, the reverse transcriptase (RT) mutations M184V, D67N and T215Y as well as the protease mutations V82A and I54V were associated with reduced CD4 declines.
HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study.
Result: The most frequently observed reverse transcriptase (RT) drug resistance mutations in NRTI-experienced patients were M184I/V (64.2%), D67N (25.9%), K70R (19.6%), K219Q/E (17.9%) and T215Y/F (13.4%).
Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Result: Among the two TAMs pathways, TAM-2 which features D67N, K70R, T215F, and K219E/Q mutations was more common than the TAM-1 which features M41L, L210W and T215Y.
Table: D67N
Discussion: Lastly, the study in one side identified an increasing common mutational pathways overtime with two thymidine non-analog (M184V and K65R) and three thymidine analog (D67N, K70R and K219E) major nucleoside reverse transcriptase inhibitor (NRTI)-associated DRMs and fo
Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.
PMID: 29026792
2017
Iranian journal of public health
HIV mutation literature information.
PMID: 
2018
PLoS medicine
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