Result: It showed that M41L, D67N, T69D, K70R, and K219R were the most common NRTI mutations that associated with the three NNRTI mutations, K103N, Y181C and G190A.
Table: D67N
Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance.
Result: Inherent levels of AZT resistance were first tested for wild-type subtype C in the absence (C-WT) or presence (C-TAMs) of TAMs (D67N, K70R, T215F/Y and K219Q).
Result: Standard TAMs (M41L, D67N, L210W, F214L, T215F/Y, K219N/E), were observed in POL, with P1 lacking NRTI TAMs.
Result: We have previously shown that the difference in AZT resistance between TAMs combination D67N, K70R, T215Y and K219Q v
Tenofovir-based regimens associated with less drug resistance in HIV-1-infected Nigerians failing first-line antiretroviral therapy.
Method: Thymidine analog mutations (TAMs) included M41L, D67N, K70R, L210W, T215F/Y, K219E/Q) that were further designated as TAM 1 (M41-L210-T215Y) or TAM 2 (D67-K70-T215F-K219).
Result: D67N and K219E were the TAMs seen with K65R in the three patients who had both.
Antiviral resistance and correlates of virologic failure in the first cohort of HIV-infected children gaining access to structured antiretroviral therapy in Lima, Peru: a cross-sectional analysis.
Result: The M184V reverse transcriptase mutation was detected in 80% of the sequenced RNA samples and tested positive in 74% and 47% by RNA-OLA and DNA-OLA, whereas thymidine associated mutations (TAMs: M41L, D67N, K70R, L210W, T215F/Y, K219Q/E) were detected in 50% of sequenced viral RNA.
Evaluation of a benchtop HIV ultradeep pyrosequencing drug resistance assay in the clinical laboratory.
PMID: 23284027
2013
Journal of clinical microbiology
Abstract: Several patients had low-abundance D67N, K70R, and M184V reverse transcriptase inhibitor mutations that persisted long after discontinuation of the drug that elicited these mutations.
Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals.
PMID: 23443042
2013
Journal of the International AIDS Society
Result: One patient had D67DN and K70KE mutations in the proviral sequence.
Table: D67N
Transmission patterns of HIV-subtypes A/AE versus B: inferring risk-behavior trends and treatment-efficacy limitations from viral genotypic data obtained prior to and during antiretroviral therapy.
Result: Thymidine analogues mutations (TAMs), selected mostly by ZDV and d4T, were prevalent (6/9; 66.66%), with type II TAMs being more frequently detected (4/9; 44.44%): K70R and K219Q (each in three cases), D67N and T215F (each in two cases).
Description of HIV-1 group M molecular epidemiology and drug resistance prevalence in Equatorial Guinea from migrants in Spain.
Discussion: For transmitted NRTI-resistance, the low presence found (with the predominance of change M184V) agrees with the study of Djoko et al., although they only found the substitution D67N as transmitted NRTI-resistance mutation.
Evaluation of WHO immunologic criteria for treatment failure: implications for detection of virologic failure, evolution of drug resistance and choice of second-line therapy in India.
PMID: 23735817
2013
Journal of the International AIDS Society
Method: Nucleoside reverse transcriptase inhibitor (NRTI) mutations included in this analysis were as follows: M184V, M184I and M184V/I for lamivudine (3TC) and emtricitabine (FTC) resistance; K65R and K70E, associated with tenofovir (TDF) resistance; thymidine analogue mutations (TAMs) M41L, D67N, K70R, L210W, T215Y, T215F, K219Q, and K219 E, associated with resistance to multiple NRTIs; and multinucleoside mutations, including the
HIV mutation literature information.
PMID: 
2014
AIDS research and therapy
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