Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaounde, Cameroon.
Result: The most frequently observed reverse transcriptase (RT) drug resistance mutations in NRTI-experienced patients were M184I/V (64.2%), D67N (25.9%), K70R (19.6%), K219Q/E (17.9%) and T215Y/F (13.4%).
HIV-1 viraemia and drug resistance amongst female sex workers in Soweto, South Africa: A cross sectional study.
The Genotyping Resistance Profile of the Pol Gene Detected in Blood of Newly Diagnosed HIV-Positive Men Is Durably Archived in the Gut Whatever the Time of Initiation of cART.
Abstract: Those mostly detected were related to the resistance to nucleos(t)ide (D67N, L210W, T215A, T69D) and nonnucleoside (K103N, V106I, V179I) inhibitors.
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile.
PMID: 27645238
2016
Antimicrobial agents and chemotherapy
Method: The virus 6TAMs, containing six resistance mutations in HIV-1 RT (M41L, D67N, K70R, L210W, T215Y, and K219Q) that confer resistance to thymidine analogs, was constructed by cloning a PCR-amplified RT-encoding fragment from HIV-infected patient-derived plasma.
Surveillance of HIV Transmitted Drug Resistance in Latin America and the Caribbean: A Systematic Review and Meta-Analysis.
Result: For this region, the most prevalent TDR mutations for the whole study period were K103N (2.0%), M184V (0.9%), M41L (0.8%), and D67N (0.6%).
Result: This decreasing trend was associated with reductions in frequency of several DR mutations including D67N, K70R, M184V, L210W,
Discussion: 3.1%, p<0.0001), with a significant reduction in the frequency of M184V and of most thymidine analogue mutations (TAM), including D67N, K70R, L210W, T215F, T215Y, and K219E.
HIV Drug Resistance in Antiretroviral-Naive Patients in Mexico After 10 Years: Is There a Difference?
PMID: 27353350
2016
AIDS research and human retroviruses
Abstract: In both groups, mutations in N88D protease inhibitor were identified, D67N and T69D were found for nucleoside reverse transcriptase inhibitors (NRTIs), and K103N was found for non-nucleoside reverse transcriptase inhibitors.
Viral Suppression and Resistance in a Cohort of Perinatally-HIV Infected (PHIV+) Pregnant Women.
PMID: 27338425
2016
International journal of environmental research and public health
Abstract: The most frequent major mutations were K103N, M184V, T215, M41L, D67N at reverse transcriptase gene and M46, I54V and V82A at protease gene.
Adherence to Pre-Exposure Prophylaxis for HIV Prevention in a Clinical Setting.
Result: The following mutations associated with nucleoside reverse transcriptase inhibitor (NRTI) drug resistance were detected: D67N, M184V, T215S, and K219Q.
HIV mutation literature information.
PMID: 
2017
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