Result: Fifteen combinations were observed among 46 ARV drug-experienced subjects with 3 TAMs; where 39% of these subjects harbored the combination M41L + T215Y + L210W, followed in 11% by combination of D67N + K70R + K219Q.
Result: In ARV drug-experienced subjects, TAMs found were T215Y/F (26.8%), K70R (15.2%), M41L (13.7%), K219E/Q (12.2%), D67N (10.9%), and L210W (7.5%) (Fig 1A).
Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication.
Abstract: Outcomes for wild-type (WT) RT and an AZT-resistant (AZT(R)) RT containing a thymidine analog mutation set-D67N, K70R, D215F, and K219Q-were compared.
Method: To construct an AZTR RT-containing version of pCMVDeltaR8.2, the following amino acid substitutions that confer resistance to AZT: D67N, K70R, T215F, and K219Q were introduced into an HIV reverse transcriptase (RT) gene fragment using overlap extension PCR, sequenced, and used to replace wild-type sequences between AgeI and BclI in pCMVDeltaR8.2 to produce pCBN103-18, which
Increasing HIV-1 Drug Resistance Between 2010 and 2012 in Adults Participating in Population-Based HIV Surveillance in Rural KwaZulu-Natal, South Africa.
PMID: 27002368
2016
AIDS research and human retroviruses
Discussion: The first was a male individual infected with a virus with multiclass resistance (NNRTI+NRTI), including two TAMs (D67N and K219Q) and the T215 revertant (T215A).
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Result: Finally, in July 2008 four out of six TAMs relevant for highly efficient AZTMP excision (M41L, D67N, T215Y and K219E, missing K70R and L210W) as well as four out of five discrimination mutations (A62V, V75I, F116Y and Q151M, lacking F77I) were present.
Result: Sequencing of the patient isolate in March 2000 revealed the presence of four TAMs (M41L, D67N, K70R, T215Y) as well as two mutations of the Q151M discrimination pathway (
Clinical, virological and phylogenetic characterization of a multiresistant HIV-1 strain outbreak in naive patients in southern Spain.
PMID: 26483513
2016
The Journal of antimicrobial chemotherapy
Abstract: BACKGROUND: We describe the characteristics of an HIV-1 strain with six viral reverse transcriptase mutations (D67N, T69N/D, V118I, V179D, T215S and K219Q), which we have called the Malaga strain.
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
PMID: 26414663
2016
AIDS research and human retroviruses
Abstract: However, TAMs were divided into three categories and M41L, L210W, and T215Y mutations were found for TAM1 in 97 (7.4%) patients, D67N, K70R, K219E/Q/N/R, T215F, and T215C/D/S mutations were detected for TAM2 in 52 (3.9%) patients, and M41L + K219N and M41L + T215C/D/S mutations were detected for the TAM1 + TAM2 profile in 22 (1.7%) patients, respectively.
Patterns of HIV-1 Drug-Resistance Mutations among Patients Failing First-Line Antiretroviral Treatment in South India.
PMID: 26385878
2016
Journal of the International Association of Providers of AIDS Care
Abstract: RESULTS: Of the study patients followed up for 6 months, 23 patients failed first-line therapy and the mutation of I135R/T/V/X, L178 I/M, M184V/I, D67N, K70R, and K103N was most common.
Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory-based phenotypes among CRF01_AE and subtype B HIV-infected individuals.
Result: Protease (PR) RAMs detected from this outlier sample were M46I, I47V and I84V, and reverse transcriptase (RT) RAMs were A62V, D67N, K70R, V75I, F116Y, Q151M and K219Q.
Result: RT RAMs were A62V, D67N, V75I, F77L, K101H, Y115F, F
Mutations in the reverse transcriptase and protease genes of human immunodeficiency virus-1 from antiretroviral naive and treated pediatric patients.
HIV mutation literature information.
PMID: 
2016
Journal of the International AIDS Society
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